Table 1

Factors to consider before selecting the therapeutic target in a patient with SLE

TimingType I IFN activation is most prominent early in the disease process and during some flares
IFN inducerSeveral IFN inducers exist and may differ between patients. Prevent generation of
IFN inducers or degrade triggers? Block sensors of IFN inducers?
IFN-producing cellsInhibit pDCs and/or other cell types as well?
Type of IFNWhich IFN(s) are most relevant in a specific patient?
IFN targetBlock IFN receptor(s) or signalling pathways?
  • IFN, interferon; pDC, plasmacytoid dendritic cell.