Table 1

Characteristics of patients without a confirmed SLE diagnosis at baseline

Positive AVISE
(n=20)
Non-positive AVISE
(n=97)
P value
Demographics
 Women95.093.8ns
 Average age at baseline52.7±12.153.9±14.7ns
Baseline diagnoses at t=0% (n)
 SLE0 (0)0 (0)ns for all
 RA15.0 (3)22.7 (22)
 UCTD65.0 (13)35.1 (34)
 Other autoimmune10.0 (2)23.7 (23)
 Non-inflammatory (OA)10.0 (2)6.2 (6)
 FM without CTD0 (0)9.3 (9)
 Discoid lupus without SLE0 (0)2.1 (2)
 Unclear0 (0)1.0 (1)
 Medications at t=0 (%)ns for all
 Hydroxychloroquine65.0 (13)49.5 (48)
 Methotrexate15.0 (3)7.2 (7)
 Mycophenolate0.00.0
 Azathioprine5.0 (1)5.2 (5)
 Other DMARDs (leflunomide and sulfasalazine)5.0 (1)4.1 (4)
 Belimumab5.0 (1)4.1 (4)
 RA biologic5.0 (1)16.5 (16)
Medications at t=2 (%)
 Corticosteroids10.0 (2)9.3 (9)ns
 Hydroxychloroquine65.0 (13)49.4 (48)ns
 Methotrexate0 (0)6.3 (6)ns
 Mycophenolate15.0 (3)0 (0)0.005
 Azathioprine5.0 (1)1.0 (1)ns
 Other DMARDs (leflunomide and sulfasalazine)0 (0)11.3 (4)ns
 Belimumab0 (0)4.1 (4)ns
 Change in diagnosis at t=280.0 (16)28.9 (28)<0.0001
  • CTD, connective tissue disease; DMARD, disease-modifying antirheumatic drug; FM, fibromyalgia ; ns, not significant; OA, osteoarthritis; RA, rheumatoid arthritis; UCTD, undifferentiated connective tissue disease.