Abstract P103 Table 1

Enriched DNA damage response/repair Gene Ontology processes and pathways in SLE B cell populations

B CELL SUBTYPE GENE ONTOLOGY PROCESSES & PATHWAYS RELATED TO DNA DAMAGE RESPONSE & REPAIR (GSEA, FDR<0.25)
Resting Naive
(CD19+IgD+CD27MTGCD24+CD38+)
• DNA DAMAGE RESPONSE SIGNAL TRANSDUCTION BY P53 CLASS MEDIATOR
• INTRINSIC APOPTOTIC SIGNALING PATHWAY IN RESPONSE TO DNA DAMAGE
• NUCLEOTIDE EXCISION REPAIR PREINCISION COMPLEX STABILIZATION
• G2M CHECKPOINT
• MISMATCH REPAIR
Transitional 3
(CD19+IgD+CD27MTG+CD24mid/ +CD38)
• ATM PATHWAY
• G2M CHECKPOINT
• BASE EXCISION REPAIR AP SITE FORMATION
• DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE
Activated Naive (CD19+IgD+CD27MTG+CD24CD38) • G2M CHECKPOINT
• GENOTOXIC DAMAGE 4HR
Isotype-Switched Memory (CD19+IgDCD27+) • CELL CYCLE CHECKPOINT
• G2 DNA DAMAGE CHECKPOINT
• DNA REPAIR
Double-Negative
(CD19+IgDCD27CXCR5)
• BASE EXCISION REPAIR
• NUCLEOTIDE EXCISION REPAIR
• MISMATCH REPAIR
• DNA REPLICATION