Table 4

Association of SLEDAI-2K manifestation with HDAS after exclusion from SLEDAI calculation†

SLEDAI manifestationsNon-HDAS visit with adjustment n/total (%)HDAS visit with adjustment n/total (%)OR (95% CI; p value)*
Manifestations with a weighting of 8
 Seizure1/4940 (0.02)2/740 (0.27)*
 Psychosis7/4946 (0.14)3/734 (0.41)2.9 (0.6 to 10.4; 0.125)
 Organic brain syndrome12/4951 (0.24)7/729 (0.96)4.0 (1.5 to 10.0; 0.004)
 Visual disturbance9/4948 (0.18)2/732 (0.27)1.5 (0.2 to 5.8; 0.604)
 Cranial nerve disorder16/4955 (0.32)3/725 (0.41)1.3 (0.3 to 3.8; 0.71)
 Lupus headache10/4949 (0.2)0/731 (0)*
 Stroke/CVA0/4949 (0)0/741 (0)*
 Vasculitis46/4985 (0.92)20/695 (2.88)3.2 (1.8 to 5.3; <0.001)
Manifestations with a weighting of 4
 Arthritis312/5521 (5.94)57/429 (13.29)1.4 (1.0 to 1.8; 0.035)
 Myositis16/4955 (0.32)11/725 (1.52)4.7 (2.1 to 10.1; <0.001)
 Urinary casts9/4948 (0.18)27/732 (3.69)28.7 (13.3 to 71.5; <0.001)
 Haematuria266/5205 (5.11)217/475 (45.68)65.1 (50.6 to 84.7; <0.001)
 Proteinuria1112/5368 (20.72)262/312 (83.97)5.4 (4.4 to 6.6; <0.001)
 Pyuria96/5035 (1.91)185/645 (28.68)19.2 (14.8 to 25; <0.001)
Manifestations with a weighting of 2
 Rash682/5166 (17.2)159/541 (30.93)2.1 (1.7 to 2.6; <0.001)
 Alopecia211/5150 (4.1)60/530 (11.32)2.1 (1.5 to 2.8; <0.001)
 Mucosal ulcers136/5075 (2.68)46/605 (7.6)2.4 (1.7 to 3.4; <0.001)
 Pleurisy64/5003 (4.87)33/677 (4.87)3.6 (2.3 to 5.5; <0.001)
 Pericarditis10/4949 (0.2)9/731 (1.23)6.1 (2.4 to 15.1; <0.001)
 Low complement2964/5166 (57.38)474/514 (92.22)3.5 (2.8 to 4.5; <0.001)
 Increased DNA binding2852/5166 (55.2)465/514 (90.47)3.2 (2.6 to 4.0; <0.001)
Manifestations with a weighting of 1
 Thrombocytopenia105/5044 (2.08)15/636 (2.36)1.0 (0.5 to 1.6; 0.867)
 Leucopenia246/5185 (4.74)28/495 (5.66)0.8 (0.5 to 1.1; 0.16)
 Fever8/4947 (0.16)11/733 (1.5)9.3 (3.8 to 24.1; <0.001)
  • *Too few data points to calculate OR.

  • †In this analysis, the SLEDAI-2K score was re-calculated based on all SLEDAI manifestations excluding the current SLEDAI-2K manifestation being investigated. Consequently, the total number of HDAS and non-HDAS visits may differ between SLEDAI manifestations.

  • CVA, cerebrovascular accident; HDAS, high disease activity status; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.