SLEDAI manifestations | Non-HDAS visit with adjustment n/total (%) | HDAS visit with adjustment n/total (%) | OR (95% CI; p value)* |
Manifestations with a weighting of 8 | |||
Seizure | 1/4940 (0.02) | 2/740 (0.27) | * |
Psychosis | 7/4946 (0.14) | 3/734 (0.41) | 2.9 (0.6 to 10.4; 0.125) |
Organic brain syndrome | 12/4951 (0.24) | 7/729 (0.96) | 4.0 (1.5 to 10.0; 0.004) |
Visual disturbance | 9/4948 (0.18) | 2/732 (0.27) | 1.5 (0.2 to 5.8; 0.604) |
Cranial nerve disorder | 16/4955 (0.32) | 3/725 (0.41) | 1.3 (0.3 to 3.8; 0.71) |
Lupus headache | 10/4949 (0.2) | 0/731 (0) | * |
Stroke/CVA | 0/4949 (0) | 0/741 (0) | * |
Vasculitis | 46/4985 (0.92) | 20/695 (2.88) | 3.2 (1.8 to 5.3; <0.001) |
Manifestations with a weighting of 4 | |||
Arthritis | 312/5521 (5.94) | 57/429 (13.29) | 1.4 (1.0 to 1.8; 0.035) |
Myositis | 16/4955 (0.32) | 11/725 (1.52) | 4.7 (2.1 to 10.1; <0.001) |
Urinary casts | 9/4948 (0.18) | 27/732 (3.69) | 28.7 (13.3 to 71.5; <0.001) |
Haematuria | 266/5205 (5.11) | 217/475 (45.68) | 65.1 (50.6 to 84.7; <0.001) |
Proteinuria | 1112/5368 (20.72) | 262/312 (83.97) | 5.4 (4.4 to 6.6; <0.001) |
Pyuria | 96/5035 (1.91) | 185/645 (28.68) | 19.2 (14.8 to 25; <0.001) |
Manifestations with a weighting of 2 | |||
Rash | 682/5166 (17.2) | 159/541 (30.93) | 2.1 (1.7 to 2.6; <0.001) |
Alopecia | 211/5150 (4.1) | 60/530 (11.32) | 2.1 (1.5 to 2.8; <0.001) |
Mucosal ulcers | 136/5075 (2.68) | 46/605 (7.6) | 2.4 (1.7 to 3.4; <0.001) |
Pleurisy | 64/5003 (4.87) | 33/677 (4.87) | 3.6 (2.3 to 5.5; <0.001) |
Pericarditis | 10/4949 (0.2) | 9/731 (1.23) | 6.1 (2.4 to 15.1; <0.001) |
Low complement | 2964/5166 (57.38) | 474/514 (92.22) | 3.5 (2.8 to 4.5; <0.001) |
Increased DNA binding | 2852/5166 (55.2) | 465/514 (90.47) | 3.2 (2.6 to 4.0; <0.001) |
Manifestations with a weighting of 1 | |||
Thrombocytopenia | 105/5044 (2.08) | 15/636 (2.36) | 1.0 (0.5 to 1.6; 0.867) |
Leucopenia | 246/5185 (4.74) | 28/495 (5.66) | 0.8 (0.5 to 1.1; 0.16) |
Fever | 8/4947 (0.16) | 11/733 (1.5) | 9.3 (3.8 to 24.1; <0.001) |
*Too few data points to calculate OR.
†In this analysis, the SLEDAI-2K score was re-calculated based on all SLEDAI manifestations excluding the current SLEDAI-2K manifestation being investigated. Consequently, the total number of HDAS and non-HDAS visits may differ between SLEDAI manifestations.
CVA, cerebrovascular accident; HDAS, high disease activity status; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.