Univariable associations of baseline serum sFas, sFasL, and sFasL/sFas ratio with SLE clinical outcomes over time
| Baseline serum sFas and sFasL | AMS >4 | Flare over time | Organ damage at last visit | Damage accrual | ||||||||
| OR | (95% CI) | P value | OR | (95% CI) | P value | OR | (95% CI) | P value | OR | (95% CI) | P value | |
| sFas | ||||||||||||
| Low | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| High | 3.01 | (1.39 to 6.52) | <0.01 | 4.38 | (1.82 to 10.51) | <0.01 | 1.67 | (0.75 to 3.71) | 0.21 | 1.88 | (0.8 to 4.45) | 0.15 |
| sFasL | ||||||||||||
| Low | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| High | 0.86 | (0.41 to 1.8) | 0.69 | 0.4 | (0.18 to 0.91) | 0.03 | 0.3 | (0.13 to 0.69) | <0.01 | 0.44 | (0.18 to 1.05) | 0.06 |
| sFasL/sFas ratio | ||||||||||||
| Low | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| High | 0.64 | (0.3 to 1.36) | 0.25 | 0.4 | (0.18 to 0.91) | 0.03 | 0.36 | (0.16 to 0.82) | 0.02 | 0.29 | (0.11 to 0.72) | <0.01 |
Low and high values were those below or equal to, or above, respectively, the median value for each cytokine.
AMS, time-adjusted mean Systemic Lupus Erythematosus Disease Activity Index 2000; sFas, soluble Fas; sFasL, soluble Fas ligand; SLE, systemic lupus erythematosus.