Univariable associations of serum sFas, sFasL, and sFasL/sFas ratio with SLE clinical parameters at baseline
| sFas | sFasL | sFasL/sFas ratio | |||||||
| Ratio of GM | (95% CI) | P value | Ratio of GM | (95% CI) | P value | Ratio of GM | (95% CI) | P value | |
| Clinical manifestations | |||||||||
| Disease activity* | |||||||||
| Overall | 1.15 | (0.99 to 1.34) | 0.07 | 0.81 | (0.65 to 1.02) | 0.08 | 0.71 | (0.55 to 0.91) | <0.01 |
| Serological | 1.02 | (0.87 to 1.2) | 0.79 | 0.96 | (0.81 to 1.14) | 0.65 | 0.94 | (0.75 to 1.18) | 0.59 |
| Renal | 1.42 | (1.19 to 1.69) | <0.01 | 1.02 | (0.84 to 1.24) | 0.85 | 0.72 | (0.55 to 0.95) | 0.01 |
| Mucocutaneous | 1.1 | (0.92 to 1.32) | 0.29 | 0.82 | (0.65 to 1.04) | 0.1 | 0.74 | (0.57 to 0.98) | 0.04 |
| Flare | 1.18 | (1 to 1.39) | 0.05 | 0.8 | (0.63 to 1) | 0.05 | 0.68 | (0.51 to 0.89) | <0.01 |
| Organ damage | 1.02 | (0.88 to 1.19) | 0.76 | 0.89 | (0.73 to 1.08) | 0.24 | 0.87 | (0.69 to 1.09) | 0.22 |
| Treatment | |||||||||
| Prednisolone | 1.10 | (0.95 to 1.27) | 0.19 | 0.75 | (0.62 to 0.91) | <0.01 | 0.68 | (0.55 to 0.84) | <0.01 |
| Hydroxychloroquine | 0.85 | (0.69 to 1.05) | 0.14 | 0.81 | (0.59 to 1.12) | 0.2 | 0.95 | (0.69 to 1.31) | 0.76 |
| Immunosuppressants | 1.05 | (0.91 to 1.21) | 0.53 | 0.67 | (0.55 to 0.82) | <0.01 | 0.64 | (0.51 to 0.8) | <0.01 |
| Laboratory markers | |||||||||
| High CRP | 1.00 | (0.85 to 1.18) | 0.96 | 0.88 | (0.72 to 1.07) | 0.2 | 0.87 | (0.65 to 1.18) | 0.38 |
| High ESR | 1.13 | (0.97 to 1.32) | 0.12 | 0.72 | (0.57 to 0.93) | 0.01 | 0.64 | (0.51 to 0.81) | <0.01 |
| Proteinuria | 1.38 | (1.13 to 1.67) | <0.01 | 1.00 | (0.79 to 1.27) | 0.99 | 0.73 | (0.59 to 0.9) | <0.01 |
| Low C3 | 1.12 | (0.96 to 1.3) | 0.14 | 0.99 | (0.8 to 1.21) | 0.89 | 0.88 | (0.69 to 1.13) | 0.32 |
| Low C4 | 0.93 | (0.81 to 1.08) | 0.36 | 0.95 | (0.79 to 1.13) | 0.55 | 1.01 | (0.79 to 1.3) | 0.93 |
| Anti-dsDNA positivity | 1.08 | (0.93 to 1.24) | 0.3 | 1.09 | (0.91 to 1.31) | 0.33 | 1.01 | (0.8 to 1.29) | 0.91 |
| Demographics | |||||||||
| Male | 1.11 | (0.91 to 1.35) | 0.32 | 0.91 | (0.7 to 1.18) | 0.48 | 0.82 | (0.58 to 1.16) | 0.26 |
| Asian ethnicity | 1.06 | (0.91 to 1.22) | 0.46 | 1.22 | (0.99 to 1.51) | 0.06 | 1.16 | (0.89 to 1.51) | 0.28 |
| RC | (95% CI) | P value | RC | (95% CI) | P value | RC | (95% CI) | P value | |
| Age (years) | 1.00 | (0.99 to 1.01) | 0.16 | 0.99 | (0.99 to 1.01) | 0.69 | 0.99 | (0.99 to 1) | 0.19 |
*Individual organ domain disease activity was assessed by SLEDAI-2K.
CRP, C reactive protein; dsDNA, double-stranded DNA; ESR, erythrocyte sedimentation rate; GM, geometric mean; RC, regression coefficient; sFas, soluble Fas; sFasL, soluble Fas ligand; SLEDAI-2K, Systemic Lupus Erythematosus Disease Activity Index 2000.