Baseline features as predictors of phenotype transition from mild or moderate to severe disease
| Transition from mild/moderate to severe disease | ||||
| Baseline | Univariable | CI | Multivariable | CI |
| Severity at diagnosis (moderate to mild) | 1.04 | 0.62 to 1.76 | ||
| SDI (0 vs ≠0) | 1.14 | 0.47 to 2.77 | ||
| Age at diagnosis | 0.96 | 0.95 to 0.99 | 1.00 | 0.97 to 1.03 |
| Disease duration | 1.10 (per year) | 1.07 to 1.14 | 1.09 | 1.04 to 1.14 |
| Sex (m/f) | 3.16 | 1.35 to 7.39 | 4.53 | 1.23 to 16.60 |
| Late-onset SLE | 0.26 | 0.12 to 0.59 | 0.32 | 0.08 to 1.28 |
| Acute cutaneous lupus | 0.97 | 0.57 to 1.64 | ||
| Renal involvement | 0.90 | 0.23 to 3.48 | ||
| Neuropsychiatric involvement | 5.28 | 1.54 to 18.07 | 6.33 | 1.22 to 32.67 |
| Leucopenia | 0.71 | 0.38 to 1.35 | ||
| Fever | 2.64 | 1.47 to 4.59 | 1.71 | 0.81 to 3.60 |
| ANA | 1.37 | 0.43 to 4.35 | ||
| dsDNA | 2.16 | 1.25 to 3.71 | 1.89 | 0.96 to 3.73 |
| Low complement | 1.94 | 1.10 to 3.39 | 1.12 | 0.55 to 2.26 |
| Anti-Sm | 1.85 | 0.74 to 4.60 | ||
Values in bold represent associations that reached statistical significance (p< 0.05).
anti-Sm, anti-Smith; dsDNA, double-stranded DNA; m/f, male/female; SDI, SLICC Damage Index; SLICC, Systemic Lupus International Collaborating Clinics.