Table 2

Multivariate analysis of variables associated with chronic (A) and moderate to severe (B) neutropaenia

VariablesChronic neutropaenia
(n=25)
Without neutropaenia
(n=779)
UnivariateMultivariate
OR (95% CI)P value*OR (95% CI)Adjusted p value†
(A) Chronic (>6 months) neutropaenia
Thrombocytopaenia, n (%)11 (45.8)102 (13.1)5.59 (2.44 to 12.8)<0.00013.90 (1.67 to 13.3)0.02
Lymphopaenia, n (%)23 (92.0)373 (47.9)12.5 (2.92 to 53.3)<0.00017.67 (2.44 to 87.5)0.0007
Anti-Ro/SSA antibodies, n (%)16 (66.7)209 (26.8)2.94 (1.23 to 6.99)0.013.41 (1.46 to 12.9)0.02
Oral ulcers, n (%)10 (40.0)207 (26.7)1.82 (0.81 to 4.12)0.161.69 (0.63 to 5.06)0.56
VariablesModerate to severe
neutropaenia
(n=20)
Without
neutropaenia
(n=779)
UnivariateMultivariate
OR (95% CI)P value*OR (95% CI)Adjusted p value†
(B) Moderate to severe neutropaenia (<1.0×109/L)
Thrombocytopaenia, n (%)10 (52.6)102 (13.1)7.34 (2.91 to 18.5)<0.00015.50 (2.34 to 22.0)0.005
Lymphopaenia, n (%)18 (90.0)373 (47.9)9.77 (2.25 to 42.4)0.00025.82 (1.73 to 64.7)0.002
Oral ulcers, n (%)10 (50.0)207 (26.8)2.73 (1.12 to 6.66)0.022.95 (1.12 to 10.7)0.04
Anti-Ro/SSA antibodies, n (%)10 (50.0)209 (40.5)1.47 (0.60 to 3.59)0.401.65 (0.58 to 5.50)0.90
  • (A) Comparison between patients with chronic neutropaenia (n=25) and without neutropaenia (n=779). Significant variables in multivariate analysis.

  • (B) Comparison between patients with moderate to severe neutropaenia (n=20) and without neutropaenia (n=779). Significant variables in multivariate analysis.

  • *Difference between patients with chronic neutropaenia or with moderate to severe neutropaenia and patients without neutropaenia using χ2 test for qualitative variables and Mann-Whitney test for quantitative variables.

  • †Adjustment for multiple testing was performed with the Benjamini and Hochberg method.

  • –, variable not entered in the multivariate model.