Table 1

Contribution of traditional and disease-related risk factors in carotid/femoral plaque formation and arterial wall thickening (IMT >0.90 mm) among patients with SLE

Plaque
(n=77)
No plaque
(n=61)
P valueIMT >0.9 mm
(n=49)
IMT ≤0.9 mm
(n=76)
P value
Traditional risk factors
Age (mean±SD), years52.1±11.235.0±10.1<0.000155.1±10.738.1±11.1<0.0001
BMI (mean±SD), kg/m226.6±5.623.7±4.60.00227.7±5.723.8±4.6<0.0001
Smoking (mean±SD), pack/years12.3±17.26.3±10.2ns13.6±19.47.3±10.6ns
FH of CVD (%)22.718.6ns20.021.4ns
Diabetes (%)10.43.3ns13.5 3.50.04
Hypertension (%)46.811.5<0.000155.816.3<0.0001
Cholesterol (mean±SD), mg/dL189±34181±41ns192±38182±37ns
HDL (mean±SD), mg/dL49±1553±23ns48±1352±22ns
LDL (mean±SD), mg/dL113±36104±33ns117±37107±33ns
Triglycerides (mean±SD), mg/dL125±48104±530.003130±53104±490.008
Premature menopause (%)11.05.0ns6.510ns
Women at menopause (%)58.115.2<0.0000171.120.7<0.00001
Disease-related risk factors
Disease duration (mean±SD), years12.4±9.75.8±5.70.000111.8±10.08.0±7.60.02
SLEDAI (mean±SD)8.6±6.89.2±7.8ns8.5±6.99.1±7.4ns
Current steroid dose (mean±SD), mg9.0±12.511.0±14.0ns6.9±11.612.3±14.30.008
Total steroid dose (mean±SD), g33.9±32.916.4±22.60.00329.7±31.224.0±29.2ns
% of patients on steroids77.980.3ns67.384.80.03
  • BMI, body mass index; CVD, cardiovascular disease; FH, family history; HDL, high-density lipoprotein; IMD, intima–media thickness; LDL, low-density lipoprotein; ns, non-significant; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.