Conventional systemic drug alternatives to antimalarial therapy
| Medication class | Medication | Evidence level* |
| Anti-inflammatory | Isotretinoin | 2B |
| Acitretin | 2B | |
| Dapsone | 4 | |
| Thalidomide | 2A | |
| Lenalidomide | 2B | |
| Sulfasalazine | 2B | |
| Immunosuppressive | Methotrexate | 4 |
| Mycophenolate mofetil (or mycophenolic acid) | 2B | |
| Azathioprine | 4 | |
| Belimumab | 2B | |
| Blood product | IVIG | 2B |
*Evidence levels adapted from the Oxford Centre for Evidence-Based Medicine.
IVIG, intravenous immunoglobulin.