TNIP1 SNPs associated with SLE and LN
| SNP | Location | Minor allele | Groups Case/control | P value | OR value | Study type | Population | Reference |
| rs7708392 | 5q33:150457485 | C G C G C C C C | 3273/12 188 465/504 1393/886 110/85 364/513 3936/3491 712/1131 1622/887 | 3.8×10−13 0.02 2.23×10−11 <0.001 2.2×10−3 1.82×10−1 3.4×10−4 2.02×10−6 | 1.27 (1.10–1.35) 0.78 (0.63–0.96) 1.76 (1.50–2.07) 4.30 (2.8–6.7) 1.40 (1.13–1.74) 1.44 1.33 (1.14–1.55) 1.36 (1.2–1.55) | GWA, SNP array Genotyping GWAS Genotyping Genotyping Genotyping Genotyping Genotyping | USA, Sweden Chinese Native American Egyptian Japanese European Swedish Hispanic | 16 17 18 19* 20* 23* 21 22 |
| rs6889239 | 5q33:150457771 | C C | 567/512 4248/3818 | 3.8×10−3 2.24×10−11 | 1.32 (1.10–1.60) 1.3 (1.2–1.4) | Genotyping Genotyping | Swedish European | 2122 22 |
| rs10036748 | 5q33:150458146 | G T | 1047/1205 1393/886 | 5.70×10−3 9.56×10−11 | 0.80 1.72 (1.46–2.02) | GWAS GWAS | Chinese Native American | 2418 18 |
| rs13168551 | 5q33:150462638 | C | 1569/1893 | 5.86×10−5 | 1.32 (1.15–1.49) | Genotyping | African-American | 22 |
| rs4958881 | 5q33:150450236 | C | 1647/1811 | 4.43×10−3 | 1.20 | Genotyping | African-American | 23* |
Minor allele is the risk allele. There is a positive association for the SNP with SLE for an OR greater than 1. For references 19*, 20* and 23*, the positive association is with SLE and LN for those SNPs and cohorts. The entire TNIP1 gene was sequenced in GWAS and that particular variant was sequenced in genotyping studies.
GWAS, genome-wide association study; LN, lupus nephritis; SNP, single-nucleotide polymorphism; TNIP1, tumour necrosis factor-α-induced protein 3-interacting protein 1.