Which ophthalmological side effects are associated with HCQ use? Mark all that apply, n (%) | |
Periorbital oedema | 0 (0) |
Keratopathy | 21 (32.8) |
Cataract formation | 2 (3.1) |
Retinopathy | 64 (100)* |
None of the above | 0 (0) |
What are the common symptoms of progressive retinal toxicity associated with CQ/HCQ use? Mark all that apply, n (%) | |
Visual colour deficits | 49 (76.6)* |
Paracentral scotoma | 54 (84.4)* |
Glare | 14 (21.9) |
Flashing lights | 18 (28.1) |
Metamorphopsia (visual distortion) | 26 (40.6) |
A 37-year-old woman with no significant past medical history (PMH) is newly diagnosed with SLE and started on HCQ. What is her approximate risk of retinal toxicity after 5 years of treatment at recommended dosages? n (%) | |
<1% | 46 (71.9)* |
3%–5% | 15 (23.4) |
5%–10% | 3 (4.7) |
10%–20% | 0 (0) |
>20% | 0 (0) |
A 37-year-old woman with no significant PMH is newly diagnosed with SLE and started on HCQ. At what point should she be considered at high risk for developing retinal toxicity? n (%) | |
1 month intro treatment | 0 (0) |
1 year into treatment | 1 (1.6) |
5 years into treatment | 17 (26.5) |
20 years into treatment | 44 (68.8)* |
No significant temporal relationship | 2 (3.1) |
When might you refer your patient prescribed HCQ to an ophthalmologist? n (%) | |
Prior to initiating therapy | 17 (26.6) |
Non-urgent within first year of treatment | 40 (62.5)* |
Non-urgent within first 5 years of treatment | 6 (9.4) |
Only after complaint of reduced visual acuity | 1 (1.5) |
*Per the American Academy of Ophthalmology guidelines.
CQ, chloroquine; HCQ, hydroxychloroquine; PMH, past medical history.