Table 4

Knowledge and attitudes

Which ophthalmological side effects are associated with HCQ use? Mark all that apply, n (%)
 Periorbital oedema0 (0)
 Keratopathy21 (32.8)
 Cataract formation2 (3.1)
 Retinopathy64 (100)*
 None of the above0 (0)
What are the common symptoms of progressive retinal toxicity associated with CQ/HCQ use? Mark all that apply, n (%)
 Visual colour deficits49 (76.6)*
 Paracentral scotoma54 (84.4)*
 Glare14 (21.9)
 Flashing lights18 (28.1)
 Metamorphopsia (visual distortion)26 (40.6)
A 37-year-old woman with no significant past medical history (PMH) is newly diagnosed with SLE and started on HCQ. What is her approximate risk of retinal toxicity after 5 years of treatment at recommended dosages? n (%)
 <1%46 (71.9)*
 3%–5%15 (23.4)
 5%–10%3 (4.7)
 10%–20%0 (0)
 >20%0 (0)
A 37-year-old woman with no significant PMH is newly diagnosed with SLE and started on HCQ. At what point should she be considered at high risk for developing retinal toxicity? n (%)
 1 month intro treatment0 (0)
 1 year into treatment1 (1.6)
 5 years into treatment17 (26.5)
 20 years into treatment44 (68.8)*
 No significant temporal relationship2 (3.1)
When might you refer your patient prescribed HCQ to an ophthalmologist? n (%)
 Prior to initiating therapy17 (26.6)
 Non-urgent within first year of treatment40 (62.5)*
 Non-urgent within first 5 years of treatment6 (9.4)
 Only after complaint of reduced visual acuity1 (1.5)
  • *Per the American Academy of Ophthalmology guidelines.

  • CQ, chloroquine; HCQ, hydroxychloroquine; PMH, past medical history.