Table 2

Basic demographics and prevalence of classification criteria attributes in gold standard case and control patient cohorts as determined by chart adjudication

Gold standard case cohort
n=472
Gold standard control cohort
n=500
Sex (% female)434 (92)458 (92)
Mean age**29.6 (SD 11.4)35 (SD 6.1)
Race (%)
 White210 (45)255 (51)
 African-American128 (27)144 (29)
 Other134 (28)101 (20)
Satisfy lupus classification criteria
 ACR4712
 SLICC4681
 EULAR/ACR4525
Classification criteria attributes (%)
 Acute cutaneous lupus407 (87)0 (0)
 Alopecia96 (20)16 (3)
 Arthritis (synovitis)409 (87)41 (8)
 Chronic cutaneous lupus120 (25)0 (0)
 DeliriumND0 (0)
 Discoid rash97 (21)1 (0.2)
 Fever81 (17)0 (0)
 Haematological disorder280 (59)10 (2)
 Haemolytic anaemia44 (9)1 (0.2)
 Leucopenia432 (92)6 (1)
 Malar rash250 (53)1 (0.2)
 Neurological disorder (ACR)27 (6)9 (2)
 Neurological disorder (SLICC)102 (22)9 (2)
 Oral ulcers220 (47)2 (0.4)
 Photosensitivity324 (69)0 (0)
 Renal disorder (ACR)165 (35)12 (2)
 Renal disorder (SLICC)178 (38)11 (2)
 Renal disorder (EULAR/ACR)101 (21)9 (2)
 Seizure31 (7)13 (3)
 Serositis174 (37)9 (2)
 Thrombocytopenia58 (13)2 (0.4)
 Anti-dsDNA Ab329 (70)3 (0.6)
 Antinuclear Ab455 (96)16 (3)
 Antiphospholipid Ab127 (27)2 (0.4)
 Anti-Smith Ab105 (22)0 (0)
 Direct Coombs test12 (3)0 (0)
 Immunological disorders361 (76)2 (0.4)
 Low complement325 (69)0 (0)
 C3265 (56)0 (0)
 C4266 (56)0 (0)
  • *For patients with SLE, age is mean age at first diagnosis of lupus; for healthy controls, age is mean age at time of data extraction.

  • ACR, American College of Rheumatology; EULAR, European League Against Rheumatism; ND, not determined; SD, Standard Deviation; SLICC, Systemic Lupus International Collaborating Clinics.