Non-responder (n=42) | Responder (n=41) | P value | |
Demographics (n (%) unless stated) | |||
Age at biopsy, years, mean (SD) | 32 (11) | 31 (9.6) | 0.455 |
Sex, female | 39 (91) | 39 (89) | 1.000 |
Race, black | 41 (95) | 38 (86) | 0.266 |
Baseline lab measures (median, IQR unless stated) | |||
Urine protein-to-creatinine ratio (g/g) | 2.7 (4.8) | 1.31 (3.7) | 0.018 |
eGFR | 92 (76) | 106 (77) | 0.534 |
Serum C3 (mg/dL), mean (SD) | 65 (30) | 71 (29) | 0.554 |
C4, mean (SD) | 15 (8.6) | 16 (7.3) | 0.761 |
Anti-dsDNA antibodies | 176 (162) | 119 (189) | 0.256 |
Serum creatinine | 1.0 (1.3) | 0.90 (0.70) | 0.269 |
White blood cell count | 5.8 (4.4) | 6.5 (6.1) | 0.504 |
Platelets | 251 (123) | 247 (113) | 0.745 |
Haemoglobin, mean (SD) | 10 (1.4) | 10 (1.4) | 0.656 |
Albumin, mean (SD) | 2.4 (0.8) | 2.6 (0.6) | 0.149 |
Baseline pathology (# patients >0, median (IQR) or # of patients (%)) | |||
Activity score | 38, 5 (5) | 35, 3 (6) | 0.091 |
Chronicity score | 36, 4 (5) | 34, 2 (2) | 0.004 |
Interstitial fibrosis | 34, 2 (1.) | 24, 1 (1) | 0.001 |
Interstitial inflammation | 30, 1 (1) | 29, 1 (1) | 0.978 |
Glomeruli | 42, 18 (13) | 41, 19 (11) | 0.539 |
Crescents | 15, 0 (2) | 20, 0 (2) | 0.382 |
Crescent:Glomeruli ratio | 15, 0 (0.2) | 20, 0 (0.08) | 0.261 |
Necrosis | 1 (1) | 2 (1) | 0.703 |
Proliferative disease, yes | 37 (86) | 32 (73) | 0.125 |
Membranous disease, yes | 23 (53) | 20 (46) | 0.454 |
Mesangial disease, yes | 3 (7) | 6 (14) | 0.484 |
Thrombotic microangiopathy (#, %) | 2 (5) | 1 (2) | 1.000 |
Induction medication use (n (%)) | |||
Prednisone, yes | 36 (86) | 38 (93) | 0.307 |
Hydroxychloroquine, yes | 34 (81) | 34 (83) | 0.815 |
Mycophenolate/Mycophenolic acid, yes | 28 (67) | 32 (78) | 0.367 |
Cyclophosphamide, yes | 14 (33) | 9 (22) | 0.361 |
Rituximab, yes | 6 (14) | 1 (2.4) | 0.109 |
Azathioprine, yes | 7 (17) | 6 (15) | 0.799 |
# immunosuppressants at baseline* | |||
0 | 0 (0) | 0 (0) | |
1–2 | 12 (29) | 10 (24) | 0.403 |
≥3 | 30 (71) | 31 (76) |
dsDNA, double stranded DNA; eGFR, estimated glomerular filtration rate.