Sensitivity analyses of persons without further autoimmune disease and with antimalarial therapy required
| Persons with incident SLE in 2016 and without further autoimmune disease (n=453) | Persons with incident SLE in 2016 and with antimalarial therapy (n=307) | |||||||
| 2015 | 2016 | 2017 | 2018 | 2015 | 2016 | 2017 | 2018 | |
| Comorbidity diagnoses | ||||||||
| Elixhauser score, mean | 1.0 | 4.1 | 4.3 | 4.4 | 1.2 | 4.0 | 4.0 | 4.2 |
| Hypertension | 14.8 | 46.8 | 49.2 | 50.6 | 16.9 | 41.0 | 44.3 | 45.3 |
| Hyperlipidaemia | 7.3 | 25.8 | 26.5 | 26.7 | 6.8 | 20.2 | 20.2 | 20.2 |
| Cerebrovascular disease | 2.2 | 8.8 | 9.7 | 10.6 | 1.6 | 7.2 | 9.4 | 11.1 |
| Thrombosis | 0.7 | 3.3 | 3.1 | 4.0 | 0.7 | 4.6 | 5.2 | 4.9 |
| Kidney disease | 2.4 | 16.3 | 18.1 | 18.3 | 2.0 | 12.1 | 14.3 | 15.6 |
| COPD | 0.7 | 2.4 | 3.3 | 3.1 | 1.0 | 3.6 | 3.9 | 2.6 |
| Hypothyroidism | 6.0 | 17.0 | 17.0 | 18.3 | 5.5 | 14.0 | 15.0 | 15.6 |
| Osteoarthritis | 6.2 | 23.8 | 24.1 | 25.2 | 7.5 | 22.5 | 22.8 | 23.5 |
| Osteoporosis | 3.3 | 19.0 | 19.2 | 20.8 | 3.6 | 16.9 | 17.6 | 18.9 |
| Fibromyalgia | 1.5 | 6.0 | 6.0 | 5.7 | 2.3 | 6.2 | 6.5 | 5.9 |
| Depression | 12.4 | 30.2 | 31.8 | 32.5 | 13.4 | 30.9 | 31.3 | 32.9 |
| Polyneuropathy | 1.8 | 6.6 | 8.2 | 9.1 | 0.0 | 0.7 | 1.0 | 1.0 |
| Solid tumour | 1.8 | 6.8 | 7.3 | 7.9 | 2.3 | 6.8 | 6.8 | 7.2 |
| Metastatic cancer | 0.4 | 0.7 | 1.3 | 1.3 | 0.3 | 0.3 | 0.7 | 0.0 |
| Specialist care | ||||||||
| Nephrologist | 1 | 12 | 13 | 14 | 2 | 12 | 12 | 13 |
| Neurologist | 3 | 10 | 8 | 8 | 4 | 9 | 8 | 9 |
| Psychiatrist | 1 | 4 | 4 | 4 | 3 | 4 | 4 | 4 |
| Diagnostics | ||||||||
| Lipid profile | 19 | 60 | 57 | 57 | 21 | 57 | 56 | 56 |
| Hospitalisation | 13 | 21 | 39 | 34 | 14 | 27 | 40 | 36 |
| Drug prescriptions | ||||||||
| Mean number of drugs | 3.3 | 4.4 | 9.4 | 9.4 | 3.6 | 5.0 | 9.4 | 9.3 |
| Cardiovascular therapy* | 15.5 | 19.2 | 57.8 | 58.1 | 16.6 | 21.5 | 53.4 | 54.1 |
| Lipid-lowering drugs | 4.9 | 6.8 | 20.8 | 23.0 | 4.6 | 5.9 | 13.4 | 16.3 |
| Osteoporosis therapy | 1.8 | 2.2 | 8.4 | 7.9 | 2.0 | 2.6 | 10.1 | 10.4 |
| Antidepressants | 7.7 | 8.4 | 21.0 | 19.2 | 8.1 | 7.5 | 17.6 | 17.3 |
| NSAID | 14.6 | 19.0 | 36.6 | 36.9 | 19.5 | 24.4 | 35.2 | 37.8 |
| Other analgesics | 10.8 | 11.0 | 30.9 | 30.7 | 10.7 | 13.7 | 29.0 | 25.1 |
| Opioids | 4.9 | 7.3 | 16.1 | 16.1 | 4.6 | 7.2 | 13.0 | 14.0 |
*Antihypertensives, beta-blockers and/or diuretics.
COPD, chronic obstructive pulmonary disease; NSAID, non-steroidal antirheumatic drug.