Neuropsychological and behavioural test performance in subjects with SLE compared with healthy controls (HC)
| Cognitive and behavioural test performance | SLE (N=74) | HC (N=74) | P value (SLE vs HC) |
| Automated Neuropsychological Assessment Metrics Mean (SD) | |||
| Simple Reaction Time visuomotor processing speed, simple motor speed, attention | 363.8 (88.0) | 321.1 (65.4) | <0.01 |
| Matching Grids visuospatial processing | 29.6 (9.9) | 34.0 (11.8) | 0.02 |
| Match to Sample working memory, visuospatial processing | 25.5 (8.6) | 31.8 (12.0) | <0.01 |
| Running Memory Continuous Performance Task vigilance, sustained attention, working memory | 73.4 (14.7) | 84.0 (15.6) | <0.01 |
| Spatial Processing Simultaneous mental rotation, visuospatial skills | 24.0 (7.0) | 26.3 (8.8) | 0.26 |
| 2×2 array Mean (SD) | |||
| Non-Spatial Memory Test working memory | 1.8 (0.6) | 2.1 (0.7) | <0.01 |
| Spatial Memory Test spatial memory | 3.6 (1.1) | 4.3 (1.6) | 0.01 |
| Beck Depression Index score, range: 0–63 Median (Q1–Q3) (range) | 9.0 (2.0–14.3) (0–44) | 1.5 (0.0–3.0) (0–34) | <0.01 |
| # BDI scores >13, n (%) | 19 (26) | 1 (1) | <0.01 |
| Numerical Rating Scale for pain, range: 0–10 n (%) of subjects with score >0 | 43 (58) | 15 (20) | <0.01 |
| ANAM fatigue score, range: 0–6 n (%) of subjects with score >2 | 31 (42) | 7 (10) | <0.01 |
| ANAM sleepiness score, range: 1–7 n (%) of subjects with score >2 | 22 (30) | 7 (10) | <0.01 |
| ANAM anger score, range: 0–6 n (%) of subjects with score >0 | 32 (43) | 9 (12) | <0.01 |
| ANAM anxiety score, range: 0–6 n (%) of subjects with score >0 | 51 (69) | 32 (43) | <0.01 |
Neuropsychological test scores are all expressed as throughput, or efficiency, scores (accuracy÷reaction time), except for Simple Reaction Time, which represents reaction time in milliseconds. All data are reported as a mean or median along with an SD or IQR, or as a frequency (%).
ANAM, Automated Neuropsychological Assessment Metrics.