Prevalence of features of SLE at the time of the first sample and at the time of the latest follow-up sample
| Feature | At sample 1 (N, (%)) | At latest follow-up sample (N, (%)) |
| Total no of patients | 484 | 369 |
| Symptoms | ||
| Alopecia | 121 (25.0) | 120 (32.5) |
| Arthritis | 114 (23.6) | 109 (29.5) |
| Arthralgia | 157 (32.4) | 160 (43.4) |
| Cranial nerve disorder | 23 (4.8) | 35 (9.5) |
| Digital ulceration | 3 (0.6) | 3 (0.8) |
| Fatigue | 287 (59.3) | 291 (78.9) |
| Mucosal ulcers | 153 (31.6) | 172 (46.6) |
| Myositis | 15 (3.1) | 29 (7.9) |
| Nephritis | 161 (33.3) | 190 (51.4) |
| New rash | 144 (29.8) | 170 (46.1) |
| Pericarditis | 62 (12.8) | 64 (17.3) |
| Pleurisy | 68 (14.0) | 75 (20.3) |
| Psychosis | 20 (4.1) | 28 (7.6) |
| Raynaud | 161 (33.3) | 157 (42.5) |
| Seizure | 38 (7.9) | 45 (12.2) |
| Vasculitis | 66 (13.6) | 82 (22.2) |
| Visual disturbance | 3 (0.6) | 8 (2.2) |
| Laboratory features | ||
| ANA | 86 (59.2)* | 18 (58.1)† |
| dsDNA | 170 (35.1) | 141 (38.2) |
| Haematuria | 77 (15.9) | 65 (17.6) |
| Haemolytic anaemia | 4 (0.8) | 7 (1.9) |
| Leucopenia | 17 (3.5) | 12 (3.3) |
| Low complement | 145 (30.0) | 128 (34.7) |
| Proteinuria | 14 (2.9) | 9 (2.4) |
| Pyuria | 179 (37.0) | 150 (40.7) |
| Thrombocytopenia | 19 (3.9) | 7 (1.9) |
| Urinary casts | 7 (1.4) | 1 (0.3) |
| No features | 3 (0.6) | 0 (0) |
Symptoms were assessed by text mining, laboratory assessments are directly taken from the EHR.
*For the first sample, 147 ANA tests were performed, 87 were positive or strong positive, 41 weak positive and 19 negative.
†For the follow-up samples, 31 ANA tests were performed, 18 were positive or strong positive, 10 weak positive and 3 negative.
dsDNA, anti-double-stranded antibodies.