Predicted Annual and 5 and 10-Yr Direct and Indirect Costs (in 2021 Canadian dollars) Stratified by (a) SLE and (b) Non-SLE NP States*
| (a) SLE NP States | |||||||
| State 1** | State 2 | State 3 |
Difference
State 1 & 2 |
Difference
State 1 & 3 |
Difference
State 2 & 3 | ||
| Direct Costs*** | 1 year | 6715 | 9020 | 10809 | 2304 (−2439, 7048) | 4093 (114, 8072) | 1789 (−3769, 7346) |
| 5 years | 35567 | 45782 | 52060 | 10215 (−12590, 33020) | 16493 (−4056, 37041) | 6278 (−20421, 32976) | |
| 10 years | 72307 | 91193 | 99496 | 18886 (−25576, 63348) | 27188 (−14884, 69261) | 8302 (−43120, 59725) | |
| Indirect Costs**** | 1 year | 24805 | 25133 | 34939 | 328 (−5191, 5846) | 10134 (4310, 15958) | 9806 (3024, 16589) |
| 5 years | 136970 | 138257 | 172674 | 1287 (−25270, 27844) | 35704 (7705, 63702) | 34417 (2800, 66033) | |
| 10 years | 289343 | 293639 | 339156 | 4296 (−48915, 57506) | 49813 (−5662, 105287) | 45517 (−15111, 106145) | |
| b) Non-SLE NP States | |||||||
| State 1 | State 2 | State 3 |
Difference
State 1 & 2 |
Difference
State 1 & 3 |
Difference
State 2 & 3 | ||
| Direct Costs*** | 1 year | 6401 | 8225 | 8868 | 1824 (−1412, 5059) | 2467 (−676, 5610) | 644 (−3117, 4404) |
| 5 years | 34587 | 41847 | 44002 | 7259 (−9411, 23930) | 9414 (−6907, 25736) | 2155 (−16778, 21088) | |
| 10 years | 70890 | 83515 | 86262 | 12625 (−22051, 47301) | 15372 (−18829, 49574) | 2747 (−35895, 41390) | |
| Indirect Costs**** | 1 year | 22866 | 28195 | 34225 | 5330 (466, 10193) | 11359 (6000, 16717) | 6029 (428, 11630) |
| 5 years | 131194 | 151794 | 171979 | 20599 (−3717, 44915) | 40785 (14979, 66591) | 20186 (−6291, 46662) | |
| 10 years | 279874 | 316701 | 342434 | 36827 (−13437, 87091) | 62560 (10663, 114457) | 25733 (−26882, 78348) | |
*Values are the mean (95% CI).
** State 1 = no NP event; State 2 = resolved NP event; State 3 = new/ongoing NP event.
*** Adjusted for age at diagnosis, race/ethnicity, and disease duration as the other predictors (sex, region, education, and smoking) were not significant.
**** Adjusted for sex, race/ethnicity, disease duration, region, education, and smoking as the other predictor (age at diagnosis) was not significant.
Boldface indicates differences which are significant as the 95% CI does not include 0.