Immunohistochemical characteristics of large B-cell lymphomas associated with rheumatic diseases
| Case no | CD3 | CD20 | CD10 | BCL6 | MUM1 | EBV | Subtype of DLBCL according to Hans’ algorithm |
| 1 | − | + | + | + | + | − | GCB |
| 2 | − | + | − | + | + | − | Non-GCB |
| 3 | − | + | − | − | + | − | Non-GCB |
| 4 | − | + | − | − | + | − | Non-GCB |
| 5 | − | + | − | + | + | − | Non-GCB |
| 6 | − | + | − | + | + | NA | Non-GCB |
| 7 | − | + | NA | NA | NA | NA | NA |
| 8 | − | + | − | − | + | − | Non-GCB |
| 9 | − | + | − | + | + | − | Non-GCB |
| 10 | − | + | − | − | + | − | Non-GCB |
| 11 | − | + | NA | NA | NA | NA | NA |
| 12 | NA | + | NA | NA | NA | NA | NA |
| 13 | − | + | − | + | − | NA | GCB |
| 14 | − | + | − | + | − | − | GCB |
| 15 | − | + | − | + | + | − | Non-GCB |
| 16 | − | + | − | + | + | − | Non-GCB |
| 17 | − | + | − | − | + | + | Non-GCB |
| 18 | − | + | NA | NA | NA | + | NA |
| 19 | − | + | NA | NA | NA | − | NA |
| 20 | − | + | NA | NA | NA | − | NA |
| 21 | − | + | − | + | + | − | Non-GCB |
| 22 | − | + | − | + | + | − | Non-GCB |
| 23 | − | + | − | − | + | − | Non-GCB |
| 24 | − | + | − | − | + | − | Non-GCB |
| 25 | − | + | − | + | + | − | Non-GCB |
| 26* | − | − | + | + | − | − | GCB |
| 27 | − | + | NA | NA | NA | NA | NA |
Case numbers 18–20 had a limited number of scattered tumour cells, making it difficult to calculate the percentage of positively stained cells.
*In this case, tumour cells were positive for CD79a and PAX5 staining.
+, positive; −, negative; DLBCL, diffuse large B-cell lymphoma; EBV, Epstein-Barr virus; GCB, germinal centre B-cell; NA, not available.