Table 3

DLE lesion characteristics based on CLASI scores in 112 Black and 71 non-Black patients

Anatomical location and lesion characteristicsBlack patients
n (%)
Non-Black patients
n (%)
P value*Multivariable
OR (95% CI)†‡§
P value†‡§
Erythema in any location99 (88)63 (89)0.944N/AN/A
Scale in any location78 (69)53 (75)0.464N/AN/A
Dyspigmentation in any location111 (99)56 (79)<0.00148.94 (5.82 to 411.77)¶<0.001
Scarring in any location100 (89)55 (77)0.030N/AN/A
 Erythema75 (59)42 (67)0.284N/AN/A
 Scale/hypertrophy58 (52)34 (48)0.607N/AN/A
 Dyspigmentation92 (82)32 (48)<0.0015.85 (2.94 to 11.61)**<0.001
 Scarring alopecia89 (79)40 (56)0.0013.00 (1.56 to 5.78)††0.001
 Non-scarring alopecia49 (44)29 (41)0.699N/AN/A
 Erythema36 (32)20 (28)0.570N/AN/A
 Scale/hypertrophy34 (30)22 (31)0.928N/AN/A
 Dyspigmentation63 (56)25 (35)0.0062.89 (1.50 to 5.54)‡‡0.001
 Scarring31 (28)14 (20)0.223N/AN/A
  • *P value was calculated with χ2 test.

  • †Blank values represented by ‘–’ indicate variables for which race was not a significant factor in the multivariable analyses.

  • ‡N/A represents values for which multivariable analyses were not performed.

  • §Predictor variables (race, age at initial visit, gender, disease duration at initial visit, follow-up duration, smoking status, presence of SLE) were included in multivariable analyses.

  • ¶Race and age at initial visit (OR=0.92, 95% CI 0.88 to 0.97, p=0.002) were significant predictors of dyspigmentation in any anatomical location.

  • **Race and follow-up duration (OR=1.17, 95% CI 1.01 to 1.36, p=0.04) were significant predictors of scalp dyspigmentation.

  • ††Race was the only significant predictor of scarring alopecia.

  • ‡‡Race and age at initial visit (OR=0.96, 95% CI 0.94 to 0.98, p=0.001) were also significant predictors of ear dyspigmentation.

  • CI, confidence interval; CLASI, Cutaneous Lupus Erythematosus Disease Area and Severity Index; DLE, discoid lupus erythematous; N/A, not available; OR, odds ratio.