MoCA cut-off | Cognitive impairment definitions* | |||||||
2 domains 1.5 SD below | 1 domain 2 SD below | 2 domains 2 SD below | All 3 definitions pooled | |||||
Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | |
<24 | 21.3% | 100.0% | 23.1% | 98.2% | 38.9% | 96.1% | 20.4% | 100.0% |
<25 | 36.2% | 97.9% | 38.5% | 94.6% | 61.1% | 90.9% | 34.7% | 97.8% |
<26 | 46.8% | 93.8% | 48.7% | 89.3% | 72.2% | 84.4% | 44.9% | 93.5% |
<27 | 72.3% | 83.3% | 74.4% | 76.8% | 88.9% | 66.2% | 69.4% | 82.6% |
<28 | 83.0% | 58.3% | 87.2% | 55.4% | 94.4% | 45.5% | 81.6% | 58.7% |
<29 | 91.5% | 35.4% | 92.3% | 32.1% | 100.0% | 26.0% | 89.8% | 34.8% |
<30 | 95.7% | 20.8% | 97.4% | 19.6% | 100.0% | 15.6% | 93.9% | 19.6% |
*Impairment defined by number of cognitive domains either 1.5 or 2 SD below healthy control group mean, all three definitions pooled into fourth cognitive impairment category.