Patient characteristics of the included studies on patients with SLE with CNS infection
| Study | Publication year | Study period (years) | Country | Study design | Gender | Age at the time of CNS infection diagnosis (years) | ||
| Female (n) | Male (n) | Mean | SD | |||||
| Baizabal-Carvallo et al36 | 2009 | 19 | Mexico | Retrospective | 24 | 1 | 27.5 | 7.4 |
| Hung et al37 | 2005 | 20.5 | Taiwan | Retrospective | 13 | 4 | 29.6 | 15.3 |
| Jiang et al38 | 2019 | 26 | China | Retrospective | 81 | 14 | 34.6 | 13.7 |
| Kim et al39 | 2011 | 12 | Korea | Retrospective | 10 | 1 | 34.6 | 3.8 |
| Vargas et al40 | 2009 | 10 | Philippines | Retrospective | 22 | 1 | 30.9 | 11.9 |
| Yang et al41 | 2006 | 10.5 | China | Retrospective | 37 | 1 | 34.3 | 11.1 |
| Total | -- | -- | -- | -- | 187 | 22 | -- | -- |
| Study | Total SLE cases | Patients with SLE with CNS infection | SLEDAI in patients with SLE with CNS infection | SLICC/ACR** Damage Index in patients with SLE with CNS infection | Interval from diagnosis of SLE to CNS infection (months) | |||
| N | N | Mean | SD | Mean | SD | Mean | SD | |
| Baizabal-Carvallo et al36 | 1411 | 25 | 10.6 | 7.8 | 2.24 | 1.78 | 57.8 | 37 |
| Hung et al37 | 3165 | 17 | 5.9 | 3 | -- | -- | 25.9 | 43.6 |
| Jiang et al38 | 8491 | 95 | 8 | 7.3 | 1.03 | 1.04 | -- | -- |
| Kim et al39 | 1420 | 11 | 11 | 1.9 | -- | -- | 64.7 | 21.9 |
| Vargas et al40 | 1580 | 23 | 7 | 4.2 | -- | -- | 55 | 36.9 |
| Yang et al41 | 1684 | 38 | 6.3 | 4.3 | -- | -- | 47.6 | 66.7 |
| Total | 17 751 | 209 | -- | -- | -- | -- | -- | -- |
CNS, Central nervous system; SLE, Systemic lupus erythematosus; SLEDAI, SLE Disease Activity Index; SLICC/ACR, Systemic Lupus International Collaborating Clinics/American College of Rheumatology.