Expected per cent of trough concentrations in pregnancy and post partum with medication non-adherence*
| HCQ cut-off (ng/mL) | 100% adherence | 80% adherence† | 60% adherence† | 40% adherence† | |
| 200 mg/day | 400 mg/day | 400 mg/day | 400 mg/day | 400 mg/day | |
| ≤50 | 0.1% | 0.1% | 0.1% | 0.3% | 2.2% |
| ≤100 | 0.6% | 0.3% | 1.2% | 5.3% | 24.2% |
| ≤150 | 27.0% | 2.5% | 7.3% | 22.4% | 57.9% |
| ≤200 | 74.4% | 9.0% | 21.3% | 46.5% | 80.4% |
Values in bold correspond to the optimal HCQ cutoff of </= 100 ng/mL.
*Example: patients taking 400 mg/day of HCQ are expected to have a trough HCQ concentration ≤100 ng/mL only 0.3% of the time if fully adherent and 24.2% of the time if taking 40% of doses.
†Corresponds to 20%, 40% and 60% non-adherence, respectively.
HCQ, hydroxychloroquine.