Table 2

Predicted HCQ pharmacokinetics throughout pregnancy and post partum*

TrimesterHalf-life (days)Apparent clearance (L/hour)Apparent volume of distribution (L)
First21.4 (16.1)42.1 (15.3)27 589 (17 248)
Second24.1 (16.7)48.8 (17.6)35 935 (19 645)
Third22.1 (12.7)53.0 (18.9)36 201 (15 627)
Post partum32.4 (20.2)33.2 (11.8)33 164 (16 478)
  • *Data presented as mean (SD) of the empirical Bayesian estimates.

  • HCQ, hydroxychloroquine.