HLA gene | HLA allele | Patients with SLE (2n=200) | Normal controls (2n=1902) | OR | 95% CI | P value | Pc value |
AC (AF) | AC (AF) | ||||||
Classical two-digit HLA allele | |||||||
HLA-DQA1 | HLA-DQA1*01 | 124 (0.620) | 827 (0.448) | 2.01 | 1.49 to 2.71 | 3.85×10–6 | 2.31×10–5 |
HLA-DQA1*06 | 22 (0.110) | 504 (0.273) | 0.33 | 0.21 to 0.52 | 5.22×10–7 | 3.13×10–6 | |
HLA-DQB1 | HLA-DQB1*03 | 46 (0.230) | 707 (0.372) | 0.51 | 0.35 to 0.74 | 7.00×10–5 | 3.50×10–4 |
HLA-DQB1*05 | 92 (0.460) | 601 (0.316) | 1.84 | 1.37 to 2.48 | 3.78×10–5 | 1.89×10–4 | |
HLA-DPA1 | HLA-DPA1*01 | 57 (0.285) | 774 (0.420) | 0.55 | 0.40 to 0.76 | 2.29×10–4 | 6.87×10–4 |
HLA-DPA1*02 | 128 (0.640) | 897 (0.486) | 1.88 | 1.39 to 2.54 | 3.70×10–5 | 1.11×10–4 | |
HLA-DPB1 | HLA-DPB1*04 | 24 (0.120) | 442 (0.240) | 0.43 | 0.28 to 0.67 | 1.27×10–4 | 1.65×10–3 |
HLA-DPB1*05 | 53 (0.265) | 329 (0.178) | 1.66 | 1.19 to 2.32 | 2.85×10–3 | 3.71×10–2 | |
HLA-DPB1*14 | 13 (0.065) | 43 (0.023) | 2.91 | 1.54 to 5.51 | 6.05×10–4 | 7.87×10–3 | |
Classical four-digit HLA allele | |||||||
HLA-DQA1 | HLA-DQA1*01:02 | 66 (0.330) | 387 (0.210) | 1.85 | 1.35 to 2.54 | 1.03×10–4 | 1.13×10–3 |
HLA-DQA1*03:01 | 3 (0.015) | 184 (0.099) | 0.14 | 0.04 to 0.43 | 7.83×10–5 | 8.61×10–4 | |
HLA-DQA1*06:01 | 22 (0.110) | 504 (0.273) | 0.33 | 0.21 to 0.52 | 5.22×10–7 | 5.74×10–6 | |
HLA-DQB1 | HLA-DQB1*03:01 | 35 (0.175) | 562 (0.296) | 0.50 | 0.36 to 0.71 | 4.06×10–4 | 6.50×10–3 |
HLA-DQB1*05:01 | 38 (0.190) | 248 (0.130) | 1.56 | 1.07 to 2.28 | 2.02×10–2 | ns | |
HLA-DQB1*05:02 | 50 (0.25) | 270 (0.142) | 2.02 | 1.42 to 2.85 | 5.21×10–5 | 8.34×10–4 | |
HLA-DPA1 | HLA-DPA1*01:03 | 56 (0.280) | 774 (0.419) | 0.54 | 0.39 to 0.74 | 1.32×10–4 | 6.61×10–4 |
HLA-DPA1*02:02 | 88 (0.440) | 570 (0.309) | 1.76 | 1.31 to 2.36 | 1.68×10–4 | 8.40×10–4 | |
HLA-DPB1 | HLA-DPB1*01:01 | 19 (0.050) | 47 (0.025) | 2.01 | 1.00 to 4.05 | 4.55×10–2 | ns |
HLA-DPB1*02:02 | 16 (0.080) | 74 (0.040) | 2.08 | 1.87 to 3.65 | 9.07×10–3 | ns | |
HLA-DPB1*04:01 | 21 (0.105) | 343 (0.186) | 0.51 | 0.32 to 0.82 | 4.45×10–3 | ns | |
HLA-DPB1*04:02 | 3 (0.015) | 99 (0.054) | 0.27 | 0.08 to 0.85 | 1.70×10–2 | ns | |
HLA-DPB1*05:01 | 53 (0.265) | 329 (0.178) | 1.66 | 1.19 to 2.32 | 2.85×10–3 | ns | |
HLA-DPB1*14:01 | 13 (0.065) | 43 (0.023) | 2.91 | 1.54 to 5.51 | 6.05×10–4 | 1.09×10–2 |
AC, allele count; AF, allele frequency; HLA, human leucocyte antigen; 2n, allelic count; ns, non-significant; Pc, corrected p value.