High platelet activation and EV levels are found in patients with SLE at baseline
| Healthy | SLE | Pvalue | |
| (n=30) | (n=98) | ||
| ATX, ng/mL | 257.8 (219.9; 340.1) | 251.4 (199.1; 333.9) | 0.2442 |
| Platelet, % | (n=30) | (n=40) | |
| PAC1+ | 3.65 (1.10; 8.50) | 7.85 (2.88; 15.75) | 0.0140 |
| PAC1+ ATX+ | 0.60 (0.20; 1.00) | 1.90 (0.60; 4.30) | 0.0042 |
| CD62P+ | 2.35 (1.70; 4.30) | 5.55 (2.33; 9.53) | 0.0059 |
| CD62P+ ATX+ | 0.70 (0.30; 0.80) | 1.35 (0.60; 4.35) | 0.0046 |
| PAC1+ CD62P+ | 0.70 (0.40; 1.40) | 2.00 (0.90; 4.98) | 0.0006 |
| PAC1+ CD62P+ ATX+ | 0.28 (0.15; 0.63) | 0.85 (0.379; 3,24) | 0.0020 |
| EVs, EVs/µL | (n=30) | (n=102) | |
| PEVs | 479 (275; 1074) | 3569 (1752; 7144) | <0.0001 |
| PS+ PEVs | 377 (221; 816) | 3228 (1601; 6260) | <0.0001 |
| REVs | 424 (296; 603) | 1936 (851; 4495) | <0.0001 |
| PS+ REVs | 91 (55; 144) | 1064 (171; 2294) | <0.0001 |
Results are presented as median (IQR), pvalue based on Wilcoxon Mann Whitney test. Significant pvalues are in bold.
ATX, autotaxin; EV, extracellular vesicle; IQR, interquartile range; PEV, platelet EV; PS+, phosphatidylserine positive; REV, red blood cell EV ; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index.