Table 3

Predictors of ESKD at second kidney biopsy

VariableUnivariable analysisMultivariable analysis
HR95% CIP valueHR95% CIP value
Age at second biopsy1.010.94 to 1.100.33
Male gender2.210.74 to 6.640.16
Time elapsed between first and second biopsy1.050.91 to 1.130.22
Use of IS at time of second biopsy0.820.28 to 2.330.72
Serum creatinine mg/dL1.611.34 to 1.91<0.0011.200.79 to 1.850.39
eGFR mL/min/1.73 m20.970.95 to 0.980.001
Proteinuria g/day1.231.11 to 1.36<0.0011.221.04 to 1.420.013
Arterial hypertension11.711.6 to 87.10.0164.90.6 to 40.40.14
Proliferative Class ISN/RPS 20037.410.99 to 54.90.050
AI1.140.99 to 1.320.0591.201.03 to 1.410.022
CI1.321.02 to 1.510.0301.411.09 to 1.820.008
  • Variables included in the model: Serum Creatinine, hypertension, proteinuria, AI, CI.

  • Significant variables at multivariable analysis are highlighted in bold

  • AI, activity index; CI, chronicity index; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease; IS, immunosuppressants; ISN/RPS, International Society of Nephrology/Renal Pathology Society.