Table 4

Subgroup analysis (Cox regression univariable models) testing itemised AI and CI scores as predictors of ESKD

VariableHR95% CIP value
Glomerular activity1.3841.029 to 1.8610.032
 Subendothelial deposits4.8241.129 to 16.3010.033
 Necrosis/karyorrhexis1.2470.329 to 4.2730.746
 Endocapillary hypercellularity2.1960.472 to 10.2070.316
 Cellular crescents2.8900.250 to 9.8250.089
 Leucocyte infiltration2.8980.766 to 10.9400.117
Glomerular chronicity1.3020.582 to 2.9150.520
Tubular activity0.6490.270 to 1.5610.334
Tubular chronicity1.6280.920 to 2.8740.090
 Tubular atrophy1.2200.354 to 4.2030.750
 Interstitial fibrosis0.7120.143 to 3.5530.679
  • Results from proportional hazards regression (Cox regression) univariable models, with ESKD as dependent variable and NIH itemised AI or CI score (ref 18) as predictors under investigation. Signifcant variables are highlighted in bold.

  • AI, activity score; CI, chronicity score; ESKD, end stage kidney disease.