Baseline characteristics of pregnancies
| All (N=216) n (%) | No low-dose acetylsalicylic acid (n=134), n (%) | Low-dose acetylsalicylic acid (n=82), n (%) | P value* | |
| Age at pregnancy, years† | 32 (30–36) | 33 (29–37) | 32 (30–36) | 0.75 |
| Disease duration† | 9 (5–13) | 8 (4–13) | 9 (6–13) | 0.26 |
| Joint involvement‡ | 160 (74.1) | 98 (73.1) | 62 (75.6) | 0.75 |
| Cutaneous involvement‡ | 143 (66.2) | 85 (63.4) | 58 (70.7) | 0.30 |
| Haematological involvement‡ | 68 (31.5) | 37 (27.6) | 31 (37.8) | 0.13 |
| Serositis‡ | 35 (16.2) | 21 (15.7) | 14 (17.1) | 0.84 |
| Hypertension | 8 (3.8) | 7 (5.3) | 1 (1.2) | 0.26 |
| Obesity | 6 (3.2) | 5 (4.3) | 1 (1.3) | 0.41 |
| Smoking | 2 (1.8) | 2 (3.4) | 0 (0.0) | 0.50 |
| First pregnancy | 96 (45.7) | 57 (43.8) | 39 (48.8) | 0.57 |
| Assisted reproduction techniques | 3 (2.1) | 1 (1.3) | 2 (3.0) | 0.60 |
| Hydroxychloroquine§ | 141 (65.3) | 81 (60.4) | 60 (73.2) | 0.07 |
| Glucocorticoids§ | 111 (51.4) | 66 (49.3) | 45 (54.9) | 0.48 |
| Azathioprine§ | 24 (11.1) | 16 (12.0) | 8 (9.8) | 0.66 |
| Ciclosporin A§ | 4 (1.9) | 0 (0.0) | 4 (4.9) | 0.04 |
| Active disease at first visit | 22 (10.8) | 16 (12.5) | 6 (7.9) | 0.36 |
| SLEDAI at first visit† | 2 (0–2) | 2 (0–3) | 2 (0–2) | 0.28 |
| Disease flares during pregnancy | 26 (12.3) | 17 (12.8) | 9 (11.5) | 0.83 |
SLEDAI: Systemic Lupus Erythematosus Disease Activity Index
Number of missing data: active disease at first visit: 12; SLEDAI at first visit: 16; hypertension: 5; obesity: 26; smoking: 103; first pregnancy: 6; medically assisted procreation: 73; disease flares during pregnancy: 5.
*P values from Fisher’s exact test for categorical variables and Kruskal-Wallis test for continuous variables.
†Median (IQR).
‡At any time during the disease course.
§During pregnancy.