Cognitive function and serological variables in patients with SLE
| SLE (n=102) n (%) | Cognitive impairment (n=47) n (%) | Normal cognition (n=54) n (%) | P value | |
| Anti-dsDNA | 43 (42) | 20 (43) | 22 (41) | 0.85 |
| Anti-chromatin | 36 (35) | 15 (32) | 21 (39) | 0.47 |
| Anti-ribosomal P | 7 (7) | 2 (4) | 4 (7) | 0.50 |
| Anti-Ro (60, 52) | 37 (36) | 18 (38) | 19 (35) | 0.75 |
| Anti-La | 30 (29) | 15 (32) | 15 (28) | 0.99 |
| Anti-Sm | 17 (17) | 7 (15) | 10 (19) | 0.63 |
| Anti-RNP (A, 68) | 29 (28) | 12 (26) | 17 (31) | 0.51 |
| Anticardiolipin | 17 (17) | 9 (20) | 7 (13) | 0.37 |
| Anti-β2 glycoprotein I | 14 (14) | 8 (17) | 5 (9) | 0.25 |
| LAC | 23 (23) | 13 (28) | 9 (17) | 0.18 |
| Anticardiolipin or anti-β2 glycoprotein I or LAC | 30 (30) | 17 (36) | 13 (24) | 0.16 |
| Anti-NR2 (peptide mix) | 15 (15) | 7 (15) | 8 (15) | 0.99 |
| Anti-NR2 (protein mix) | 12 (12) | 4 (9) | 8 (15) | 0.31 |
| Anti-GFAP | 25 (25) | 15 (32) | 9 (17) | 0.07 |
| Anti-MPP1 | 34 (33) | 14 (30) | 19 (35) | 0.56 |
| Low C3 | 14 (14) | 4 (9) | 9 (17) | 0.22 |
| Low C4 | 29 (28) | 15 (32) | 13 (24) | 0.38 |
| Elevated neurofilament light chains | 23 (23) | 13 (28) | 10 (19) | 0.27 |
dsDNA, double-stranded DNA; GFAP, glial fibrillar acidic protein; LAC, lupus anticoagulant; MPP1, M-phase phosphoprotein 1; NR2, N-methyl-D-aspartic acid receptor 2; RNP, ribonucleoprotein.