Table 2

Baseline and follow-up data of patients with lupus nephritis with IgG4 deposits in the PLA2R-negative subgroup and PLA2R-positive subgroup

PLA2R-negative subgroup, n=17PLA2R-positive subgroup, n=13P value
Age (years)35.76±12.6330.08±12.860.24
Gender (male/female)3/142/110.87
Positive anti-dsDNA antibody, n (%)9 (52.9)3 (23.1)0.10
SLEDAI score13.29±4.1810.31±4.380.07
IgG (mg/dL)1424.71±731.891021.75±426.740.09
IgM (mg/dL)104.59±68.59124.00±76.040.49
IgA (mg/dL)282.29±121.33211.67±110.400.12
C3 (mg/dL)39.82±24.1673.08±44.680.03
C4 (mg/dL)7.41±7.4016.58±12.190.02
WCC (×109/L)3.51±1.566.56±4.750.04
HB (g/dL)(g/L)93.94±22.69114.12±22.560.02
PLT (×109/L)140.12±48.75212.62±62.250.01
Urine protein (g/g)3.40 (2.30, 4.44)2.54 (0.53, 6.64)0.62
Haematuria119.90 (60.90, 287.55)57.20 (23.15, 114.35)0.79
Serum albumin (g/L)23.94±7.1226.54±10.390.45
Serum creatinine (μmol/L)75.00 (65.00, 104.00)61.00 (53.00, 82.00)0.94
eGFR (mL/min/1.73 m2)79.94±30.95103.15±37.210.07
Pathological classification, n (%)0.09
 Ⅱ0 (0)0 (0)
 Ⅲ/Ⅳ9 (52.9)3 (23.1)
 Ⅴ4 (23.5)8 (61.5)
 Ⅲ/Ⅳ+Ⅴ4 (23.5)2 (15.4)
Crescent, n (%)5 (29.4)3 (23.1)0.69
Glomerular sclerosis, n (%)7 (41.2)5 (38.5)0.88
C3 deposition, n (%)11 (64.7)3 (23.1)0.02
C4 deposition, n (%)9 (52.9)3 (23.1)0.09
C1q deposition, n (%)12 (70.6)7 (52.8)0.60
IgM deposition, n (%)13 (76.5)7 (53.8)0.19
IgA deposition, n (%)14 (82.4)4 (30.8)0.01
IgG deposition, n (%)16 (94.1)12 (92.3)0.84
 IgG1 deposition17 (100)12 (92.3)0.25
 IgG2 deposition16 (94.1)7 (53.8)0.01
 IgG3 deposition14 (82.4)7 (53.8)0.04
Multisite deposits under EM (≥2 sites), n (%)17 (100)13 (100)
 Subendothelial deposit10 (58.8)5 (38.5)0.27
Immunosuppressive treatment, n (%)0.67
 Steroids+cyclophosphamide4 (23.5)1 (7.7)
 Steroids+mycophenolate mofetil4 (23.5)3 (23.1)
 Steroids+ciclosporin/tacrolimus4 (23.5)4 (30.8)
 Steroids+others5 (29.4)5 (38.5)
Follow-up (months)33.56±12.0334.54±12.210.57
Treatment response, n (%)0.59
 CR11 (64.7)6 (46.2)
 PR4 (23.5)5 (41.7)
 No response2 (11.8)2 (16.7)
Renal outcome events, n (%)1 (5.9%)0 (0%)0.37
  • CR, complete response; dsDNA, double-stranded DNA; eGFR, estimated glomerular filtration rate; EM, electron microscopy; HB, haemoglobin; PLA2R, phospholipase A2 receptor; PLT, platelet; PR, partial response; SLEDAI, Systemic Lupus Erythematous Disease Activity Index; WCC, white cell count.