Table 1

Clinical and laboratory features associated with renal disease activity

Feature	P value* Rise in serum creatinine (N=35)	P value* Rise in R-SLEDAI (N=90)
Institution	0.0388	0.1178
Race	0.0154	0.0800
Age	0.8346	0.9765
Male gender	<0.0001	0.6360
LN class	0.0002	0.7791
Anti-RNP	0.6489	0.2299
Anti-phospholipid	0.0035	0.7202
Anti-Sm	0.2519	0.2785
Anti-dsDNA	0.3158	0.3118
Urine casts	0.0147	XX
Haematuria	0.0015	XX
Pyuria	0.2360	XX
Proteinuria	<0.0001	XX
R-SLEDAI score	<0.0001	XX
Baseline serum creatinine	0.2720	0.0001
Oral methotrexate†	<0.0001	0.3138
Azathioprine	0.6454	0.0009
Mycophenolate mofetil†	0.0003	0.2364
Rituximab†	<0.0001	0.7128
Systemic steroids†	0.0002	0.5716

Significant values are bolded.
*Χ² (categorical) or Welch-Satterthwaite t-test (continuous). XX indicates that the variable is part of the R-SLEDAI.
†Medications are listed when the p value is significant.
LN, lupus nephritis; R-SLEDAI, renal Systemic Lupus Erythematosus Disease Activity Index.