Clinical and histological predictors of KFI (univariate and multivariate analysis)
| Univariate analysis | Multivariate analysis 1 | Multivariate analysis 2 | |||||||
| OR | CI | P | OR | CI | P | OR | CI | P value | |
| Histological features at first kidney biopsy | |||||||||
| Cellular/fibrocellular crescents>1* | 5.805 | 1.275 to 26.441 | 0.023 | ||||||
| Clinical features at second kidney biopsy | |||||||||
| Serum creatinine | 1.329 | 1.123 to 1.572 | 0.001 | ||||||
| Proteinuria>3.5 g/die | 3.239 | 1.457 to 7.197 | 0.004 | ||||||
| Arterial hypertension | 3.384 | 1.374 to 8.337 | 0.008 | ||||||
| Histological features at second kidney biopsy | |||||||||
| Activity Index >3 | 3.808 | 1.516 to 9.564 | 0.004 | 3.230 | 1.275 to 8.183 | 0.013 | |||
| Cell/fibrocell crescents>1* | 4.141 | 1.406 to 12.199 | 0.010 | 4.207 | 1.416 to 12.500 | 0.010 | |||
| Hyaline deposits>1* | 2.836 | 1.216 to 6.614 | 0.016 | ||||||
| Chronicity Index>4 | 3.476 | 1.544 to 7.824 | 0.003 | 2.905 | 1.285 to 6.566 | 0.010 | |||
| Fibrous crescents>1* | 2.902 | 1.148 to 7.335 | 0.024 | ||||||
| Interstitial fibrosis >1* | 2.498 | 1.114 to 5.598 | 0.026 | 2.525 | 1.120 to 5.691 | 0.025 | |||
*These variables were categorised as: 0+1 vs 2+3, being: 0 if absent; 1+ if mild (in less than 25% of glomeruli and/or in tubulointerstitial cortex); 2+ if moderate (in between 25% and less than 50% of glomeruli and/or in tubulointerstitial cortex) and 3+ if severe (in more than 50% of glomeruli and/or in tubulointerstitial cortex).
KFI, kidney function impairment.