Table 2

The number of T-cell subsets in patients with LN with or without immunosuppressants

T-cell phenotypePatients without immunosuppressants (n=12)Patients with immunosuppressants (n=12)P value
CD4+ (% lymphocytes)48.5 (38.1, 71.1)40.3 (22.8, 76.6)0.39
CD4+ (cell/μL)176.8 (30.0, 359.6)161.3 (44.7, 471.7)0.71
Naïve CD4+ (% CD4+)58.3 (29.2, 85.1)49.1 (24.8, 97.7)0.81
Naïve CD4 (cell/μL)75.7 (20.1, 171.3)123.8 (19.2, 442.8)0.58
CD4+ memory (% CD4+)41.7 (14.9, 70.8)50.9 (2.3, 75.2)0.81
CD4+ memory (cell/μL)74.0 (6.9, 231.8)59.2 (8.0, 174.9)0.62
CD4+ TCM (% CD4+)10.5 (6.9, 16.9)8.6 (7.0, 12.3)0.46
CD4+ TCM (cell/μL)21.2 (8.7, 29.2)11.3 (3.8, 26.6)0.19
CD4+ TEM (% CD4+)53.1 (14.9, 120.6)57.5 (16.4, 93.1)0.88
CD4+ TEM (cell/μL)78.5 (18.6, 151.0)72.0 (20.5, 116.6)0.77
CD4+ Treg (cell/μL)1.8 (0.5, 3.6)0.2 (0.2, 1.1)0.04
CD8+ (% lymphocytes)46.5 (18.6, 55.7)42.4 (17.0, 66.3)0.67
CD8+ (cell/μL)133.2 (15.5, 352.5)133.1 (50.7, 613.5)0.58
Naïve CD8+ (% CD8+)68.6 (40.1, 83.8)81.8 (64.8, 95.8)0.007
Naïve CD8+ (cell/μL)86.6 (7.5,189.5)99.7 (40.4, 559.5)0.33
CD8+ memory (% CD8+)31.5 (16.2, 59.9)18.3 (4.2, 35.2)0.007
CD8+ memory (cell/μL)33.7 (7.8, 173.8)20.64 (4.4, 93.5)0.46
CD8+ TCM (% CD8+)1.91 (0.2, 4.7)0.54 (0.3, 1.0)0.06
CD8+ TCM (cell/μL)21.2 (8.7, 29.2)0.98 (0.4, 3.9)0.24
CD8+ TEM (% CD8+)31.0 (13.5, 39.7)19.5 (14.2, 21.4)0.028
CD8+ TEM (cell/μL)52.5 (12.9, 124.5)62.5 (8.6, 84.3)0.88
  • Data are expressed as medians (10th–90th percentile). P values less than 0.05 are presented in bold font.

  • The frequency of CD8+ TM was significantly lower, while the frequency of CD8+-naïve T cells was higher in patients with LN with immunosuppressants compared with those in patients with LN without immunosuppressants.

  • LN, lupus nephritis; TCM, central memory T cells; TEM, effector memory T cells; TM, memory T; Treg, regulatory T.