Operating characteristics of the ACR-1997, SLICC-2012 and EULAR/ACR-2019 classification criteria in the SLE and control cohorts
| AUC | Cut-off value | Sensitivity | Specificity | Accuracy | PPV | NPV | +LR | −LR | |
| ACR-1997 | 0.972 (0.957 to 0.983) | 4 | 82.1% (77.7% to 86.0%) | 96.4% (94.0% to 98.0%) | 89.6% (87.1% to 91.7%) | 95.4% (92.5% to 97.2%) | 85.5% (82.5% to 88.1%) | 22.578 (13.470 to 37.845) | 0.186 (0.148 to 0.232) |
| SLICC-2012 | 0.986 (0.975 to 0.993) | 4 | 98.0% (95.9% to 99.2%) | 92.2% (89.1% to 95.7%) | 95.0% (93.1% to 96.4%) | 92.0% (89.1% to 94.2%) | 98.1% (96.1% to 99.1%) | 12.578 (8.918 to 17.741) | 0.022 (0.010 to 0.045) |
| EULAR/ACR-2019 | 0.983 (0.970 to 0.991) | 10 | 97.4% (95.2% to 98.8%) | 91.4% (88.2% to 94.0%) | 94.3% (92.4% to 95.9%) | 91.2% (88.2% to 93.5%) | 97.5% (95.4% to 98.7%) | 11.368 (8.200 to 15.761) | 0.028 (0.015 to 0.053) |
ACR, American College of Rheumatology; AUC, area under curve; EULAR, European Alliance of Associations for Rheumatology; −LR, negative likelihood ratio; +LR, positive likelihood ratio; NPV, negative predictive value; PPV, positive predictive value; SLICC, Systemic Lupus International Collaborating Clinics.