Results of the CPET, patient reported outcomes and 10MWT (n=16)
| Pre-training | Post-training | Δ (post-pre) | P value | |
| CPET variables (mean±SD) | ||||
| Peak exercise measures | ||||
| Treadmill time (s) | 837 (203) | 916 (153) | +79 (86) | 0.002* |
| VO2 (mL/kg/min) | 21.7 (3.5) | 23.1 (3.8) | +1.4 (2.0) | 0.013* |
| WR (W) | 174 (55) | 195 (46) | +21 (24) | 0.004* |
| HR (beats/min) | 157 (17) | 154 (16) | −2 (12) | 0.443 |
| RER | 1.18 (0.11) | 1.17 (0.11) | −0.01 (0.07) | 0.445 |
| Submaximal exercise measures (at the anaerobic threshold) | ||||
| Treadmill time (s) | 341 (144) | 435 (130) | +93 (82) | < 0.001** |
| VO2 (mL/kg/min) | 12.1 (2.4) | 13.3 (2.6) | +1.2 (1.1) | <0.001** |
| HR (beats/min) | 108 (15) | 106 (10) | −2 (8) | 0.193 |
| WR (W) | 44 (35) | 68 (30) | +24 (21) | < 0.001** |
| Patient reported outcomes (mean±SD) | ||||
| FSS average all domains combined | 4.6±1.2 | 3.1±1.4 | −1.4±1.0 | <0.0001** |
| 10MWT | ||||
| Distance (m) | 925 (131) | 1009 (121) | +84 (66) | <0.001** |
| Performance fatigability index | 1.11 (0.17) | 0.99 (0.12) | −0.12 (0.09) | <0.001** |
| Perceived fatigability index | 4.88 (1.92) | 4.45 (2.11) | −0.43 (1.55) | 0.501 |
*p=<0.05; **p=<0.001. Paired two-tailed, t-test were used for all results, except peak HR, VO2 for the AT, performance fatigability index and perceived fatigability index where a Wilcoxon signed-rank test was used. Shapiro-Wilk normality test was performed to evaluate normality assumption. No adjustments were made for multiple comparisons.
CPET, cardiopulmonary exercise test; FSS, Fatigue Severity Scale; HR, heart rate; 10MWT, 10-minute walk test; RER, respiratory exchange ratio; VO2, oxygen consumption; WR, work rate.