Final PK model parameter estimates
| Parameter | Estimate | RSE (%) | 2.5th percentile | Bootstrap median | 97.5th percentile |
| Ka (1/hour) | 1.15 (fixed) | — | — | — | — |
| Tlag (hour) | 0.39 (fixed) | — | — | — | — |
| CL/F (L/hour/70 kg) | 60.6 | 20.7 | 29.3 | 61.5 | 73.9 |
| V/F (L) | 73 540 | 31.1 | 13 586 | 75 615 | 141 017 |
| V/FDHCQ (L) | 6788 | 72.9 | 0.2 | 5850 | 14 902 |
| CL/FDHCQ (L/hour/70 kg) | 22.2 | 19.5 | 9.9 | 22.2 | 29.5 |
| Exponential scaling of weight/70 on HCQ CL/F | 0.59 | 85.5 | −1.1 | 0.6 | 1.2 |
| Exponential scaling of weight/70 on DHCQ CL/F | 1.20 | 45.4 | −0.6 | 1.1 | 2.0 |
| Between subject variability (%CV) | |||||
| CL/F | 34.8 | 5.8 | — | — | — |
| V/F | 81.5 | 32.4 | — | — | — |
| CL/FDHCQ | 47.9 | 9.6 | — | — | — |
| Residual error | |||||
| Proportional error, HCQ (%) | 39.3 | 22.2 | 0.3 | 0.4 | 0.5 |
| Proportional error, DHCQ (%) | 45.7 | 20.1 | 0.4 | 0.4 | 0.5 |
CL/F, apparent oral clearance; CV, coefficient of variation; DHCQ, desethylhydroxychloroquine; HCQ, hydroxychloroquine; Ka, absorption rate constant; PK, pharmacokinetics; RSE, relative SE; Tlag, lag time after oral administration; V/F, apparent volume of distribution.