Abstract 621 Table 2

Correlations Between IFN Scores and Serum KYN/TRP Pathway Metabolite Levels in SLE Subjects According to ISG Expression Subgroup. SLE subjects were assigned to 1 of 3 subgroups: “IFN high” (Z-IFN score ≥2 SD above HC mean), “IFN low” (Z-IFN score ≥1 to <2) or “IFN similar to HC” (Z-IFN score <1). In each subgroup, correlations between both IFN scores (derived from ISG-A and the 19 type I ISG) and metabolite ratios are displayed.

ISG Expression SubgroupIFN Score Method(z-scores) KYN/TRP
(rs)		pQA/KA
(rs)		p
IFN high(N=36) ISG-A 0.490 0.002* 0.129 0.453
19 Type I ISG 0.487 0.003* 0.216 0.205
IFN low(N=23) ISG-A -0.174 0.427 -0.286 0.187
19 Type I ISG 0.269 0.215 -0.210 0.335
IFN similar to HC(N=13) ISG-A 0.170 0.578 -0.126 0.681
19 Type I ISG 0.242 0.426 0.000 1.000

  • * remained significant after Benjamini-Hochberg correction for multiple comparisons