Abstract 503 Table 3

Multivariable Cox Regression Analysis of Cardiovascular Disease

Risk Factors	Model 1		Model 2
Risk Factors
HR (95%CI)	P-value	HR (95%CI)	P-value

**Social Determinants of Health**
Perceived stress scale (per unit ↑)	1.23 (1.14-1.32)	<0.001
Everyday discrimination scale (per unit ↑)			2.83 (2.05-3.90)	<0.001
*Socio-Demographics*
Age (per 10 years ↑)	1.50 (1.20-1.88)	<0.001	1.43 (1.13-1.80)	0.002
Disease duration (per 5 years ↑)	1.14 (1.01-1.29)	0.036	1.11 (0.98-1.25)	0.1
Female gender	0.80 (0.27-2.36)	0.68	1.19 (0.40-3.57)	0.76
African American race (ref: White)	1.27 (0.69-2.34)	0.45	0.71 (0.38-1.33)	0.29
Marital status (ref: Currently Married) Ever Married	1.05 (0.65-1.71)	0.84	0.94 (0.58-1.54)	0.82
Never Married	1.28 (0.74-2.21)	0.37	1.07 (0.62-1.84)	0.82
Work status (ref: Employed) Off work force	1.51 (0.73-3.11)	0.26	2.21 (1.08-4.52)	0.031
Unemployed	1.98 (1.02-3.85)	0.043	3.00 (1.51-5.94)	0.002
Insurance (ref: Private) Medicare/Medicaid	0.71 (0.38-1.32)	0.28	0.69 (0.37-1.29)	0.25
None	0.65 (0.28-1.55)	0.34	0.46 (0.16-1.26)	0.13
**Disease Severity**
Disease activity (SLAQ¹, per 3 units ↑)	0.94 (0.87-1.03)	0.17	0.95 (0.87-1.03)	0.18
Organ damage (BILD², per 1 unit ↑)	1.22 (1.10-1.35)	<0.001	1.23 (1.11-1.37)	<0.001
Glucocorticoid duration(per 5 years ↑)	1.13 (0.97-1.33)	0.11	1.09 (0.93-1.28)	0.29
Hydroxychloroquine	0.88 (0.56-1.38)	0.57	1.01 (0.63-1.60)	0.98
*CVD Traditional Risk Factors*
Hypercholesterolemia	0.86 (0.52-1.42)	0.56	1.03 (0.63-1.69)	0.91
Hypertension	1.67 (1.00-2.79)	0.051	1.99 (1.16-3.41)	0.013
Diabetes	0.75 (0.40-1.40)	0.37	0.74 (0.40-1.38)	0.34
Smoker	0.99 (0.63-1.56)	0.96	0.93 (0.59-1.48)	0.76
Obesity	1.97 (1.27-3.07)	0.003	1.74 (1.10-2.76)	0.018
Physical inactivity	1.70 (0.99-2.92)	0.054	1.93 (1.11-3.36)	0.02
Family History	1.11 (0.68-1.81)	0.67	1.16 (0.71-1.90)	0.56

¹ Systemic Lupus Activity Questionnaire; ² Self-Administered Brief Index of Lupus Damage. CVD=cardiovascular disease; HR=hazard ratio; CI=confidence interval.