Univariable and multivariable logistic regression analyses: baseline predictors of no response at 6 months
| Univariable analysis | Model 3: without pathology | Model 4: with pathology | |||||||
| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
| Female | 0.467 | 0.163 to 1.339 | 0.156 | ||||||
| Age, years | 1.044 | 1.013 to 1.075 | 0.004 | ||||||
| SLE duration >3 months | 5.808 | 2.547 to 13.996 | 0.000 | 5.036 | 2.156 to 12.350 | 0.000 | 2.517 | 1.012 to 7.226 | 0.048 |
| Hypertension | 4.035 | 1.481 to 10.993 | 0.006 | 3.068 | 1.097 to 9.555 | 0.039 | 2.517 | 0.820 to 8.580 | 0.118 |
| SLEDAI | 0.927 | 0.854 to 1.005 | 0.066 | ||||||
| Low C3 | 0.279 | 0.114 to 0.683 | 0.005 | ||||||
| Low C4 | 0.384 | 0.173 to 0.853 | 0.019 | ||||||
| Coombs’ test | 0.314 | 0.118 to 0.841 | 0.021 | ||||||
| Proteinuria, g/24 hours | 1.014 | 0.948 to 1.083 | 0.691 | ||||||
| Microscopic haematuria, /uL | 0.999 | 0.999 to 1.000 | 0.042 | ||||||
| Serum creatinine, μmoI/L | 1.003 | 0.997 to 1.009 | 0.393 | ||||||
| eGFR, mL/min/1.73 m2 | 0.987 | 0.957 to 1.017 | 0.386 | ||||||
| Activity index | 0.924 | 0.840 to 1.016 | 0.103 | ||||||
| Chronicity index | 1.949 | 1.477 to 2.572 | 0.000 | 1.757 | 1.371 to 2.414 | 0.000 | |||
| Methylprednisolone pulses | 0.421 | 0.180 to 0.988 | 0.047 | ||||||
| C-index | 0.746 (0.658 to 0.833) | 0.833 (0.756 to 0.910) | 0.011 | ||||||
eGFR, estimated glomerular filtration rate; SLEDAI, SLE Disease Activity Index.