Multivariable logistic regression models of COVID-19 outcomes in patients with SLE
| Mortality OR (95% CI) | Mechanical ventilation OR (95% CI) | Hospitalisation OR (95% CI) | ICU excluding mechanical ventilation OR (95% CI) | |
| SLE Disease Activity | ||||
| Mild (reference value) | 1 | 1 | 1 | 1 |
| Moderate | 1.76 (0.66 to 4.69) p=0.26 | 1.59 (0.68 to 3.74) p=0.29 | 2.01 (1.31 to 3.07) p=0.001 | 1.02 (0.50 to 2.08) p=0.95 |
| Severe | 2.38 (0.85 to 6.66) p=0.10 | 5.83 (2.60 to 13.07) p<0.001 | 3.97 (2.37 to 6.65) p<0.001 | 0.90 (0.38 to 2.12) p=0.85 |
All models were adjusted for Belimumab in 6 months before positive COVID-19. Additionally, model for 30-day mortality was additionally adjusted for age, race and insurance type. Model for 30-day mechanical ventilation was adjusted for age, COVID-19 diagnosis quarter, skilled nurse facility in 3 months before positive COVID-19 and severe obesity. Model for 30-day hospitalisation was adjusted for age, COVID-19 diagnosis quarter, smoking status, insurance type and region. Model for 30-day ICU excluding ventilation was adjusted for age, severe obesity and region. Association with Garris index levels of severity.
COVID-19, coronavirus disease 19; ICU, intensive care unit; SLE, systemic lupus erythematosus.