Table 2

Overview of genes and cytokines

ModulesSelected genes*Cytokines measured on ELLA Simple PlexCytokines measured with ELISA
M1.2 IFNIFI44IL-6CXCL13†
IFIT1TNFαIFNλ‡
IFIT3IL-8†IL-17‡
Ly6eCCL2†IL-23‡
MxAIL-10
M5.12 IFNPSMB9IFNγ
ISG20IFNα (pan)
NCOA7IFNβ†
SP140CXCL10†
TAP1IFNα2†
NeutrophilDEFA4TGF-β1†
BPIIL-1β‡
DEFA3/DEFA1IL-12‡
CEACAM8IL-2‡
CEACAM6IL-4‡
Plasma cellIGJ
TXNDC5
  • *Details can be found in Wahadat et al.18

  • †Cytokines which were measured in the replication cohort.

  • ‡Cytokines that were positive in less than 20% of the samples patients and thus were excluded from further analysis.

  • CCL2, chemokine ligand 2; IFN, interferon; IL, interleukin; TGF-β1, transforming growth factor beta 1; TNF, tumour necrosis factor.