Modules | Selected genes* | Cytokines measured on ELLA Simple Plex | Cytokines measured with ELISA |
M1.2 IFN | IFI44 | IL-6 | CXCL13† |
IFIT1 | TNFα | IFNλ‡ | |
IFIT3 | IL-8† | IL-17‡ | |
Ly6e | CCL2† | IL-23‡ | |
MxA | IL-10 | ||
M5.12 IFN | PSMB9 | IFNγ | |
ISG20 | IFNα (pan) | ||
NCOA7 | IFN↠| ||
SP140 | CXCL10† | ||
TAP1 | IFNα2† | ||
Neutrophil | DEFA4 | TGF-β1† | |
BPI | IL-1β‡ | ||
DEFA3/DEFA1 | IL-12‡ | ||
CEACAM8 | IL-2‡ | ||
CEACAM6 | IL-4‡ | ||
Plasma cell | IGJ | ||
TXNDC5 |
*Details can be found in Wahadat et al.18
†Cytokines which were measured in the replication cohort.
‡Cytokines that were positive in less than 20% of the samples patients and thus were excluded from further analysis.
CCL2, chemokine ligand 2; IFN, interferon; IL, interleukin; TGF-β1, transforming growth factor beta 1; TNF, tumour necrosis factor.