Cumulative* damage and mortality
| Damage | Total | Male | Female | P value |
| Age at first damage | ||||
| Mean±SD | 42.2±0.9 | 47.8±10 | 41.4±12.8 | 0.01 |
| Median (IQR 25%–75%) | 42 (33–50) | 48 (43–53) | 40 (32–50) | |
| Disease duration at first damage | ||||
| Mean±SD | 9.5±8.7 | 5.1±6.4 | 10.2±8.9 | 0.002 |
| Median (IQR 25%–75%) | 8 (2–15) | 2 (0.5–9.5) | 8 (2–16) | |
| SDI >0, n (%) | ||||
| 1 year | 39/406 (9.6) | 10/48 (20.8) | 29/358 (8.1) | 0.005 |
| 5 years | 58/339 (17.1) | 11/32 (34.4) | 47/307 (15.3) | 0.006 |
| 10 years | 82/258 (31.8) | 10/22 (45.4) | 72/236 (30.5) | 0.15 |
| SDI | ||||
| Median (IQR 25%–75%) | ||||
| At 1 year | 1 (1–1) | 1 (1–1) | 1 (1–1) | 0.37 |
| At 5 years | 1 (1–2) | 1 (1–2) | 1 (1–1) | 0.92 |
| At 10 years | 1 (1–2) | 2 (1–2) | 1 (1–2) | 0.49 |
| Disease-related damage, n (%) | ||||
| At 1 year | 26/40 (65) | 8/9 (88.9) | 18/31 (58.1) | 0.08 |
| At 5 years | 34/68 (50) | 6/11 (54.5) | 28/57 (49.1) | 0.82 |
| At 10 years | 50/89 (56.2) | 6/10 (60) | 44/79 (55.7) | 0.8 |
| At last visit | 104/155 (67.1) | 15/21 (71.4) | 89/134 (66.4) | 0.65 |
| Renal damage, n (%) | ||||
| At 1 year | 9/38 (23.7) | 3/9 (33.3) | 6/29 (20.7) | 0.44 |
| At 5 years | 12/63 (19) | 3/10 (33) | 9/53 (17) | 0.34 |
| At 10 years | 23/89 (25.8) | 3/10 (33) | 20/79 (25.3) | 0.75 |
| At last visit | 40/141 (28.4) | 6/18 (33.3) | 34/123 (27.6) | 0.62 |
| Age at CKD development (years) | ||||
| Mean±SD | 42.6±15.1 | 47±10.26 | 41.8±15.88 | 0.45 |
| Disease duration at CKD development (years) | ||||
| Mean±SD | 9.8±9.3 | 7.17±8.97 | 10.28±9.47 | 0.46 |
| Median (IQR 25%–75%) | 8.5 (1–15) | 5 (0–10) | 8.5 (2.5–15.0) | |
| GC-related damage at 1 year, n (%) | ||||
| At 1 year | 4/37 (10.8) | 0/9 | 4/28 (14.3) | 0.23 |
| At 5 years | 13/62 (21) | 2/8 (25) | 11/54 (20.3) | 0.76 |
| At 10 years | 23/89 (25.8) | 5/10 (50) | 18/79 (22.8) | 0.06 |
| At last visit | 88/158 (55.7) | 6/14 (42.9) | 82/144 (56.9) | 0.31 |
| Cancer (after disease onset), n (%) | ||||
| At 10 years | 10/89 (10.2) | 1/8 (12.5) | 8/81 (9.9) | 0.54 |
| At last visit | 24/417 (5.7) | 3/51 (5.9) | 21/366 (5.7) | n.s. |
| POF (after disease onset), n (%) | ||||
| At 10 years | n.a. | n.a. | 11/89 (12.36) | n.a. |
| At last visit | 18/366 (4.9) | |||
| CV events ever, n (%) | 38/414 (9.2) | 6/51 (11.8) | 32/363 (8.8) | 0.49 |
| Age at first CV event (years) | ||||
| Mean±SD | 47.2±2 | 53.3±3.45 | 46±2.22 | 0.16 |
| Median (IQR 25%–75%) | 47 (40–57) | 54 (44–60) | 46 (38–57) | |
| Disease duration at first CV event | ||||
| Mean±SD | 14.3±1.6 | 10.83±2.66 | 15.03±1.82 | 0.34 |
| Median (IQR 25%–75%) | 14 (8–22) | 11 (9–15) | 14 (7–25) | |
| Deaths, n (%) | 16/417 (3.8) | 4/51 (7.8) | 12/366 (3.3) | |
| Age at death (years) | ||||
| Mean±SD | 49.7±15.6 | 61±12.12 | 46±15.3 | 0.16 |
| Median (IQR 25%–75%) | 54 (37–61) | 54 (54–75) | 47 (35–60) | |
| Disease duration at death (years) | ||||
| Mean±SD | 18.7±10.2 | 21.3±5.5 | 18.1±11.2 | 0.48 |
| Median (IQR 25%–75%) | 18.5 (11–26) | 21 (16–27) | 16 (7–26) | |
| Cause of death, n (%) | ||||
| Infection | 4/16 (25) | 1/4 (25) | 3/12 (25) | n.s. |
| Disease activity | 2/16 (12.5) | 0/4 (0) | 2/12 (16.7) | n.s. |
| CV disease | 3/16 (18.7) | 1/4 (25) | 3/12 (25) | n.s. |
| Cancer | 5/16 (31.2) | 1/4 (25) | 4/12 (33.3) | n.s. |
| Unknown | 2/16 (12.5) | 1/4 (25) | 0/12 (0) | n.s. |
Statistically significant p-values are in bold.
*After disease onset.
CKD, chronic kidney disease; CV, cardiovascular; GC, glucocorticoid; n.a., not available; n.s., not significant; POF, premature ovarian failure; SDI, SLE Damage Index.