Table 2

SNPs included in the PRSs

SNP	Risk allele	Gene	RAF*	OR†	SLE B cell PRS	SLE B cell activation PRS	Publication‡
rs2230926	G	TNFAIP3	0.06	2.03	×	×	Morris et al44
rs11073328	T	RASGRP1	0.13	1.94	×		Armstrong et al45
rs8076347	T	IKZF3	0.05	1.93	×	×	Lessard et al46
rs150518861	A	LAT2	0.02	1.66	×	×	Julià et al47
rs7726414	T	SKP1	0.05	1.45	×		Bentham et al48
rs4810485	T	CD40	0.26	1.43	×	×	Langefeld et al49
rs13277113	A	BLK	0.32	1.39	×		Lee et al50
rs6679677	A	PTPN22	0.15	1.39	×		Bentham et al48
rs7829816	T	LYN	0.16	1.30	×	×	Harley et al51
rs2286672	T	PSMB6	0.08	1.25	×		Bentham et al48
rs9899849	A	GPS2	0.26	1.21	×	×	Wang et al52
rs930297	A	GRB2	0.09	1.20	×		Langefeld et al49
rs10028805	G	BANK1	0.28	1.20	×	×	Bentham et al48
rs3024505	A	IL10	0.18	1.19	×	×	Gateva et al53
rs597808	A	PTPN11	0.51	1.18	×		Bentham et al48
rs1432296	T	REL	0.19	1.18	×		Langefeld et al49
rs907715	G	IL21	0.31	1.16	×	×	Hughes et al54
rs1966115	A	IL7	0.27	1.14	×	×	Langefeld et al49
rs6871748	T	IL7R	0.28	1.12	×	×	Wang et al52
rs3087243	G	CTLA4	0.38	1.12	×	×	Wang et al52

*RAF in the patient cohort.
†ORs for SLE from published articles used in calculation of the PRSs.
‡Articles from which SNPs were identified had >1000 patients in study and reported SNPs were at GWAS significance level (p<5×10^–8).
GWAS, genome-wide association study; PRSs, polygenic risk scores; RAF, risk allele frequency; SNPs, single nucleotide polymorphisms.