Sensitivity and specificity of significant microvascular C5b-9 (ie, 10 or more positive staining vessels) in non-lesional skin biopsy compared with traditional biomarkers of LN disease activity
| Sensitivity (%) | Specificity (%) | |
| Positive C5b-9 deposition | 62.5 | 87.5 |
| Elevated dsDNA | 100 | 42.8 |
| Low complements | 75 | 57.1 |
| Pyuria | 87.5 | 62.5 |
| Haematuria | 87.5 | 100 |
| uPCR >0.5 | 100 | 57.1 |
Haematuria greater than 5 red blood cell/hpf. Pyuria greater than 5 white blood cell/hpf. Hypocomplementemia and dsDNA determined by testing laboratory’s reference values.
dsDNA, double-stranded DNA; LN, lupus nephritis; uPCR, urine protein creatinine ratio.