Baseline demographics and patient characteristics of the SPOCS population by SLEDAI-2K and IFNGS category
| Overall (N=823) | SLEDAI-2K | IFNGS | |||||
| <10 (n=343) | ≥10 (n=241) | Nominal p value | High (n=522) | Low (n=217) | Nominal p value | ||
| Age, years | n=823 | n=343 | n=241 | 0.001 | n=522 | n=217 | <0.001 |
| Mean±SD | 45.3±13.9 | 46.6±14.2 | 42.8±13.7 | 43.1±13.6 | 50.7±12.9 | ||
| Median (IQR) | 45.0 (34.0–55.0) | 47.0 (36.0–57.0) | 41.0 (33.0–51.0) | 42.0 (32.0–54.0) | 51.0 (42.0–59.0) | ||
| Age >40 years, n (%) | 503 (61.1) | 229 (66.8) | 121 (50.2) | <0.001 | 283 (54.2) | 168 (77.4) | <0.001 |
| Male, n (%) | 56 (6.8) | 28 (8.1) | 14 (5.8) | 0.278 | 33 (6.3) | 15 (6.9) | 0.767 |
| Race, n (%) | n=779 | n=321 | n=229 | 0.892 | n=483 | n=213 | <0.001 |
| Asian | 71 (9.1) | 34 (10.6) | 20 (8.7) | 50 (10.4) | 10 (4.7) | ||
| Black | 128 (16.4) | 53 (16.5) | 39 (17.0) | 96 (19.9) | 15 (7.0) | ||
| White | 541 (69.5) | 217 (67.6) | 159 (69.4) | 311 (64.4) | 179 (84.0) | ||
| Other | 39 (5.0) | 17 (5.3) | 11 (4.8) | 26 (5.4) | 9 (4.2) | ||
| Ethnicity, n (%) | n=722 | n=279 | n=217 | n=449 | n=196 | ||
| Hispanic or Latino | 113 (15.7) | 49 (17.6) | 36 (16.6) | 0.776 | 87 (19.4) | 20 (10.2) | 0.004 |
| BMI kg/m2 | n=727 | n=297 | n=221 | 0.017 | n=458 | n=195 | <0.001 |
| Mean±SD | 27.1±6.8 | 27.5±7.1 | 26.1±6.5 | 26.6±6.5 | 29.0±7.3 | ||
| Median (IQR) | 26.1 (22.0–30.8) | 26.3 (22.3–31.1) | 24.9 (21.0–29.3) | 25.4 (21.8–29.8) | 27.8 (23.5–32.7) | ||
| BMI category, n (%) | n=727 | n=298 | n=221 | 0.190 | n=458 | n=195 | 0.005 |
| Underweight | 33 (4.5) | 16 (5.4) | 15 (6.8) | 25 (5.5) | 4 (2.1) | ||
| Normal | 284 (39.1) | 106 (35.7) | 96 (43.4) | 186 (40.6) | 63 (32.3) | ||
| Overweight | 212 (29.2) | 88 (29.6) | 60 (27.2) | 136 (29.7) | 58 (29.7) | ||
| Obese | 198 (27.2) | 87 (29.3) | 50 (22.6) | 111 (24.2) | 70 (35.9) | ||
All p values are nominal; there have been no adjustments for multiplicity. Subgroups do not total overall population n due to missing data.
BMI, body mass index; IFNGS, type I interferon gene signature; SLEDAI-2K, SLE Disease Activity Index-2000; SPOCS, SLE Prospective Observational Cohort Study.