Comparison of SELENA-SLEDAI, SLEDAI-2K and BILAG-2004
| Criterion | SELENA-SLEDAI | SLEDAI-2K | BILAG-2004 |
| Number of items | 24 | 24 | 97 (divided into 9 domains) |
| Scoring | Each item is scored as 0 (not present) or 1 (present) | Each item is scored as 0 (not present) or 1 (present) | Each item is scored on a scale of 0–4 |
| Maximum score | 105 | 105 | Letter-based system |
| Organ involvement | Covers various organ systems and clinical manifestations (non-exhaustive) | Covers various organ systems and clinical manifestations (non-exhaustive) | Comprehensive assessment across nine domains |
| Capture of partial improvement/worsening | Cannot capture partial improvement | Cannot capture partial improvement | Has more granularity to capture partial improvement or worsening |
| Advantages | Simplicity in scoring and use | Simplicity in scoring and use | Comprehensive assessment across domains |
| Used in clinical trials and research | Widespread adoption | Suitable for research and clinical trials | |
| Limitations | Omission of certain SLE features | Omission of certain SLE features | Time consuming and complex |
| Fixed weights for each item | Fixed weights for each item | Primarily suited for research |
BILAG-2004, British Isles Lupus Assessment Group 2004; SELENA-SLEDAI, Safety of Estrogens in SLE National Assessment-SLE Disease Activity Index; SLEDAI-2K, SLE Disease Activity Index 2000.