Clinical and demographic characteristics of the 4 patients with lupus pericarditis treated with rilonacept
| Patient No | Age (years) | Sex | Lupus clinical features | Notable comorbidities | CRP | Ineffective treatments | Response |
|---|---|---|---|---|---|---|---|
| 1 | 44 | F | Serositis, arthritis, thrombocytopenia, leukopenia, alopecia, and ANA. | Inflammatory bowel disease | Low | Hydroxychloroquine, azathioprine, methotrexate, mycophenolate, colchicine, corticosteroids, ibuprofen, belimumab, rituximab, tofacitinib, certolizumab, anakinra. | Complete resolution of pleurisy and pericardial chest pain |
| 2 | 42 | F | Serositis, arthritis, oral ulcers, alopecia, pericarditis, pleurisy, fever, class I lupus nephritis, ANA, anti-dsDNA, anti-Smith, anti-RNP, and low C3/C4. | Stroke | High | Hydroxychloroquine, azathioprine, methotrexate, corticosteroids, ibuprofen, anakinra. | Complete symptoms resolution |
| 3 | 33 | F | Serositis, arthritis, oral ulcers, interstitial lung diseaseANA, anti-dsDNA, anti-RNP | Low | Hydroxychloroquine, azathioprine, methotrexate, mycophenolate, belimumab, ibuprofen, colchicine, corticosteroids. | Resolution of pleurisy, pericardial chest pain improved >40% | |
| 4 | 26 | F | Serositis, arthritis, photosensitivity, ANA, anti-dsDNA, anti-RNP, anti-Ro, anti-La, Coombs test, and low complement | Strokes | Unknown | hydroxychloroquine, indomethacin, azathioprine, colchicine, methotrexate, and rituximab | Complete resolution of chest pain (persistent arthritis) |