Continuous variables are presented as median (1st-3rd quartile) and compared with Mann-Whitney test; categorical variables are presented as number/number available data (%) and compared with Chi-square test/Fisher’s exact test. *= ‘extra-criteria’ according to Syndey APS criteria 2006
| Patients’ characteristics | All patients n=258 | Intra-renal involvement n=17 | No intra-renal involvement n=241 | p value |
|---|---|---|---|---|
| Male sex | 56/258 (21.7) | 6/17 (35.3) | 50/241 (20.7) | 0.218 |
| Caucasians | 244/258 (94.6) | 15/17 (88.2) | 229/241 (95.0) | 0.233 |
| Age at disease onset, years | 32.0 (25.0–44.0) | 29.0 (24.0–28.0) | 33.0 (25.0–44.0) | 0.377 |
| Thrombotic APS | 173/258 (67.1) | 6/17 (35.3) | 167/241 (69.3) | 0.004 |
| Obstetric APS | 109/202 (53.9) | 5/11 (45.5) | 104/191 (54.5) | 0.561 |
| Catastrophic APS | 4/258 (1.6) | 3/17 (17.6) | 1/241 (0.4) | 0.001 |
| ‘Extra-criteria’ APS* | 19/258 (7.4) | 8/17 (47.1) | 11/241 (4.6) | <0.001 |
| Thrombotic + obstetric APS | 36/202 (17.8) | 2/11 (18.2) | 34/191 (17.8) | 1.000 |
| Thrombocytopenia | 29/258 (11.2) | 6/17 (35.3) | 23/241 (9.5) | 0.006 |
| Heart valve lesions | 21/258 (8.1) | 2/17 (11.8) | 19/241 (7.9) | 0.637 |
| Livedo reticularis | 22/258 (8.5) | 1/17 (5.9) | 21/241 (8.7) | 1.000 |
| Epilepsy | 17/258 (6.6) | 4/17 (23.5) | 13/241 (5.4) | 0.018 |
| Single aPL profile | 87/250 (34.8) | 2/15 (13.3) | 85/235 (36.2) | 0.072 |
| Double aPL profile | 59/250 (23.6) | 4/15 (26.7) | 56/235 (23.8) | 0.761 |
| Triple aPL profile | 103/250 (41.2) | 9/15 (60.0) | 94/235 (40.0) | 0.127 |
| LA+ | 165/254 (64.9) | 17/17 (100.0) | 148/237 (62.4) | 0.002 |
| aCL+ | 171/257 (66.5) | 11/16 (68.8) | 160/241 (66.4) | 0.846 |
| aβ2GPI+ | 190/251 (75.7) | 11/16 (68.8) | 179/235 (76.2) | 0.548 |
| ANA+ | 125/255 (49.0) | 6/17 (35.3) | 119/238 (50.0) | 0.241 |
| anti-ENA+ | 17/240 (7.1) | 2/16 (12.5) | 15/224 (6.7) | 0.316 |
| anti-DNA+ | 0/241 (0.0) | 0/17 (0.0) | 0/224 (0.0) | 1.000 |
| C3, g/dL | 101.1 (88.0–118.0) | 108.5 (101.3–122.5) | 101.0 (87.5–118.0) | 0.477 |
| C4, g/dL | 19.0 (13.0 -24.0) | 18.0 (12.5–23.5) | 19.0 (13.0–24.0) | 0.790 |