Health-related quality of life comparison between patients in severe disease activity (SDA) vs non-SDA according to SLE-DAS (>9.90), BILAG-2004 (numerical score >11) and SLEDAI-2K (>12)
| SLE-DAS Non-SDA vs SDA | BILAG-2004 Non-SDA vs SDA | SLEDAI-2K Non-SDA vs SDA | ||||
|---|---|---|---|---|---|---|
| p* | Cohen’s d (95%CI) | p* | Cohen’s d (95%CI) | p* | Cohen’s d (95%CI) | |
| LupusQoL | ||||||
| Physical Health | <0.0001 | 0.56 (0.37–0.75) | 0.0002 | 0.35 (0.16–0.54) | 0.1795 | 0.16 (-0.10–0.42) |
| Pain | <0.0001 | 0.58 (0.39–0.77) | 0.0001 | 0.35 (0.16–0.55) | 0.4527 | 0.06 (-0.20–0.32) |
| Planning | <0.0001 | 0.49 (0.29–0.68) | 0.0003 | 0.30 (0.11–0.49) | 0.2072 | 0.13 (-0.13–0.39) |
| Intimate relationship | 0.0002 | 0.33 (0.14–0.53) | 0.0099 | 0.24 (0.04–0.44) | 0.4939 | 0.07 (-0.20–0.34) |
| Burden to others | <0.0001 | 0.44 (0.25–0.63) | <0.0001 | 0.41 (0.22–0.60) | 0.0422 | 0.25 (-0.01–0.52) |
| Emotional health | <0.0001 | 0.44 (0.25–0.63) | 0.0011 | 0.31 (0.12–0.50) | 0.0158 | 0.32 (0.06–0.58) |
| Body Image | 0.0002 | 0.31 (0.11–0.50) | 0.0001 | 0.39 (0.19–0.58) | 0.0230 | 0.24 (-0.02–0.51) |
| Fatigue | <0.0001 | 0.52 (0.33–0.71) | 0.0001 | 0.39 (0.20–0.58) | 0.0699 | 0.23 (-0.03–0.49) |
| EQ-5D Index Score | <0.0001 | 0.47 (0.27–0.66) | 0.0003 | 0.33 (0.14–0.52) | 0.7710 | -0.02 (-0.28–0.24) |
| EQ-5D VAS | <0.0001 | 0.49 (0.30–0.68) | 0.0001 | 0.38 (0.19–0.57) | 0.3352 | 0.15 (-0.11–0.41) |
| FACIT-F | <0.0001 | 0.60 (0.41–0.79) | 0.0001 | 0.40 (0.21–0.59) | 0.3125 | 0.12 (-0.14–0.38) |
| PtGA | <0.0001 | 0.47 (0.28–0.66) | <0.0001 | 0.41 (0.22–0.60) | 0.1903 | 0.19 (-0.07–0.45) |
Non-SDA: Non-Severe Disease Activity; PtGA: Patient Global Assessment; SDA: Severe Disease Activity. *Mann-Whitney test.